CEA Grenoble/LITEN/DTNM, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
Published: June 2011
AI Article Synopsis
Article Abstract
An innovative sensor for the detection of nerve agents in the gas phase based on a carbon nanotube field-effect transistor was developed. A high sensitivity to organophosphorus gases was obtained by modifying gold electrodes with specific tailor-made self-assembled monolayers.
Aim: This pilot study aimed to determine whether contrast-enhanced ultrasound (CEUS) is effective for measuring the free distal segment length of the internal carotid artery (FDS-ICA) in carotid body tumours (CBTs).
Materials And Methods: Thirty-seven patients with 38 confirmed CBTs were enrolled. Before surgery, all patients underwent grey scale ultrasound (US), colour Doppler US (CDU), and CEUS.
Samarium-doped nanohydroxyapatite is a biomaterial with nerve regeneration activity and bioimaging. In this work, Sm/HAp; (Ca Sm (PO)(OH)) (0 ≤ ≤ 1) was synthesized using the hydrothermal method and thermally treated from 200 to 800 °C. The samples were characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, and luminescence spectroscopy.
Exposure to organophosphorus nerve agents irreversibly inhibits acetylcholinesterase and may lead to cholinergic crisis and seizures. Although benzodiazepines are the standard of care after nerve agent-induced status epilepticus, when treatment is delayed for up to 30 min or more, refractory status epilepticus can develop. Adult male rodents are often utilized for evaluation of therapeutic efficacy against nerve agent exposure.
Eleven new chromane meroterpenoids (1-11), along with 24 known ones (12-35) were isolated from Rhododendron capitatum, a Tibetan medicine. Their structures were determined via extensive spectroscopic methods. The absolute configurations of 1 and 2 were determined by comparison of the experimental and theoretically calculated ECD data.
Chemical warfare nerve agents (CWNAs) are potent and irreversible inhibitors of acetylcholinesterase (AChE). Oxime reactivators are an important part of the standard treatment for CWNA exposure as they can reactivate inhibited AChE. Evaluating the oxime candidates of interest in biological samples requires analytical detection methods and oxime reactivators as a class of compounds have historically been notoriously difficult to isolate, detect and analyze in an analytical laboratory, and there are currently no sensitive or robust analytical detection methods in the literature.
