In this paper we review the main medical programs from the Universidad Nacional Autonoma de Mexico (UNAM) faculty of medicine in the first seventy-five years of twentieth century. We have selected those instances that are representative of special moments in the development of Mexican medical knowledge, and also corresponding to the need to prepare medical students in view of social demands. The first programs are those of Ignacio Chavez in 1934, concerned mainly with the introduction into the curricula of medical specialties such as cardiology or neurology. After those, the 1956 and 1960 programs are mentioned and briefly analyzed; both were founded on the concern to develop a clinical reasoning in the student. Finally, the 1974 Integral General Medicine Program directed its interest to social and environmental themes.
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