(E)-Benzaldehyde (2,4,6-trichloro-phen-yl)hydrazone.

Acta Crystallogr Sect E Struct Rep Online

College of Chemical Engineering and Materials Science, Zhejiang University of Technology, People's Republic of China.

Published: January 2011

The title compound, C(13)H(9)Cl(3)N(2), was obtained from a condensation reaction of benzaldehyde and 2,4,6-trichloro-phenyl-hydrazine. The mol-ecule assumes an E configuration with the phenyl ring and trichloro-phenyl ring located on opposite sides of the C=N bond. The phenyl ring is oriented at a dihedral angle of 42.58 (12)° with respect to the tricholorophenyl ring. In the crystal, the mol-ecules are linked via N-H⋯N hydrogen bonds, forming supra-molecular chains running along the c axis. π-π stacking is present between parallel trichloro-phenyl rings of adjacent mol-ecules, the face-to-face and centroid-centroid distances being 3.369 (14) and 3.724 (2) Å, respectively.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051786PMC
http://dx.doi.org/10.1107/S160053681100328XDOI Listing

Publication Analysis

Top Keywords

phenyl ring
8
e-benzaldehyde 246-trichloro-phen-ylhydrazone
4
246-trichloro-phen-ylhydrazone title
4
title compound
4
compound c13h9cl3n2
4
c13h9cl3n2 condensation
4
condensation reaction
4
reaction benzaldehyde
4
benzaldehyde 246-trichloro-phenyl-hydrazine
4
246-trichloro-phenyl-hydrazine mol-ecule
4

Similar Publications

Flower-like tailored carbon nitride oligomer as an excellent aggregation-induced electrochemiluminescence emitter for sensitive immunoassay of neuron-specific enolase via dual quenching by bimetallic phenolic networks.

J Colloid Interface Sci

January 2025

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China. Electronic address:

The adjustment of the electrochemiluminescence (ECL) of polymeric carbon nitride (CN) is essential for its application in sensitive immunoassays. However, such modification through aggregation-induced emission (AIE) has not yet been reported. Herein, aggregation-induced ECL in CN oligomer (CNO) was induced through the introduction of a rotatable imine moiety, with the resulting material exhibiting excellent performance in the targeted immunodetection of neuron-specific enolase.

View Article and Find Full Text PDF

In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances.

Arch Toxicol

January 2025

School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, 530004, People's Republic of China.

Over the past decade, fentanyl-type new psychoactive substances (F-NPS) have emerged as the most representative synthetic opioids in third-generation drugs. These substances are characterized by their "low" fatal dose and parent drug levels in biological matrices, "fast" rates of derivatization and metabolism, and "many" derivatization sites and analogs. The low levels of parent fentanyl NPS in biological matrices complicate their detection, necessitating the use of characteristic metabolites as biomarkers for forensic analysis.

View Article and Find Full Text PDF

Enantioselective [3+2] Annulation of Aldimines with Alkynes by Scandium-Catalyzed C-H Activation.

Angew Chem Int Ed Engl

January 2025

RIKEN, Organometallic Chemistry Laboratory, 2-1 Hirosawa, 351-0198, Wako, Saitama, JAPAN.

The enantioselective [3+2] annulation of readily accessible aldimines with alkynes via C-H activation is, in principle, a straightforward and atom-efficient route for synthesizing chiral 1-aminoindenes, which are important components in a wide array of natural products, bioactive molecules, and functional materials. However, such asymmetric transformation has remained undeveloped to date due to the lack of suitable chiral catalysts. Here, we report for the first time the enantioselective [3+2] annulation of aldimines with alkynes via C-H activation using chiral half-sandwich scandium catalysts.

View Article and Find Full Text PDF

This study presents a comprehensive exploration of the synthesis of novel compounds targeting Chagas Disease (CD) caused by Trypanosoma cruzi. It is a global health threat with over 6-7 million infections worldwide. Addressing challenges in current treatments, the investigation explores diverse compound classes, including thiazoles, thiazolidinone, imidazole, pyrazole, 1,6-diphenyl-1H-pyrazolo[3,4-b] pyridine, pyrrole, naphthoquinone, neolignan, benzeneacyl hydrazones, and chalcones-based compounds.

View Article and Find Full Text PDF

Suitable structural modifications of the functional groups at N-substituent of (-)-cis-N-normetazocine nucleus modulate the affinity and activity profile of related ligands toward opioid receptors. Our research group has developed several compounds and the most interesting ligands, LP1 and LP2, exhibited a dual-target profile for mu-opioid receptor (MOR) and delta-opioid receptor (DOR). Recent structure-affinity relationship studies led to the discovery of novel LP2 analogs (compounds 1 and 2), which demonstrated high MOR affinity in the nanomolar range.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!