In the title compound, C(18)H(16)N(2)O(5)S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.078 (1) Å (r.m.s. deviation = 0.046 Å). The dihedral angle between the coumarin ring system and the toluene ring (r.m.s. deviation = 0.004 Å) is 2.77 (1)°. The crystal packing is stabilized by C-H⋯O and N-H⋯O inter-molecular hydrogen bonds generating C(8), C(9) and C(11) chains and R(2) (2)(14), R(2) (2)(23) and R(4) (3)(13) ring graph sets.
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http://dx.doi.org/10.1107/S1600536810054620 | DOI Listing |
Future Med Chem
December 2024
Chemistry Department, Faculty of science(Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Aim: Emerging resistance among pathogens necessitates the development of novel antimicrobial agents. As a result, we aimed to synthesize new coumarins and study their antimicrobial activity with the hope of obtaining effective drugs.
Method: A series of coumarins were synthesized, characterized, and assessed for antimicrobial activity using broth microdilution and agar diffusion methods against Gram-positive (), Gram-negative () bacteria, and fungi ().
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences, Ibn Zohr University, 80060, Agadir, Morocco.
Polycystic ovarian syndrome is a heterogeneous endocrine disorder characterized by ovarian cysts, anovulation, endocrine variations, which includes oligo-amenorrhea along with associated subfertility and hyperandrogenism manifested as acne, hirsutism, and male-pattern alopecia. Coumarins are fused benzene and pyrone ring systems that exhibit a wide spectrum of bioactivities. This study aimed to investigate the effects of 3-acetyl coumarin (3-AC) on polycystic ovarian syndrome in female rats.
View Article and Find Full Text PDFFuture Med Chem
January 2025
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Aim: Developing new antimicrobial agents in response to the urgent challenge of antimicrobial resistance.
Methods: Synthesis of the targeted coumarins, elucidation of their structures using spectroscopic tools, and investigation of their antimicrobial activity.
Results: Coumarin-pyrazole with CF in the 3-position of the pyrazole ring displayed the lowest minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) with values of 1.
Acc Chem Res
December 2024
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.
ConspectusSynthetic extracellular matrix (ECM) engineering is a highly interdisciplinary field integrating materials and polymer science and engineering, chemistry, cell biology, and medicine to develop innovative strategies to investigate and control cell-matrix interactions. Cellular microenvironments are complex and highly dynamic, changing in response to injury and disease. To capture some of these critical dynamics , biomaterial matrices have been developed with tailorable properties that can be modulated in the presence of cells.
View Article and Find Full Text PDFChemphyschem
November 2024
Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, NSW, 2006, Australia.
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