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Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats.
Stem Cell Res Ther
December 2024
National Colorectal Disease CenterNanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, Jiangsu, People's Republic of China.
Background: Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may cause fecal incontinence and lower quality of life due to large surgical wounds and potential sphincter damage. Human umbilical cord-derived MSCs (hUC-MSCs) and their exosomes (hUCMSCs-Exo) may promote wound healing.
Methods: This study assessed the efficacy, mechanisms, and safety of these exosomes in treating complex perianal fistulas in SD rats.
Clinical Spectrum and Prognosis of Atypical Autosomal Dominant Polycystic Kidney Disease Caused by Monoallelic Pathogenic Variants of IFT140.
Am J Kidney Dis
December 2024
Service de Néphrologie, Hémodialyse et Transplantation Rénale, Centre de référence MARHEA, CHRU Brest, Brest, France; Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Brussels, Belgium. Electronic address:
Rationale & Objective: Monoallelic predicted Loss-of-Function (pLoF) variants in IFT140 have recently been associated with an autosomal dominant polycystic kidney disease (ADPKD)-like phenotype. This study sought to enhance the characterization of this phenotype.
Study Design: Case series.
Inclusive AI for radiology: Optimising ChatGPT-4 with advanced prompt engineering.
Clin Imaging
December 2024
Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
This letter responds to the article "Encouragement vs. liability: How prompt engineering influences ChatGPT-4's radiology exam performance," offering additional perspectives on optimising ChatGPT-4 for Radiology applications. While the study highlights the significance of prompt engineering, we suggest that addressing additional key challenges such as age-related diagnostic needs, socio-economic diversity, data security, and liability concerns is essential for responsible AI integration.
View Article and Find Full Text PDFInfantile achalasia cardia: A rare case report of a 3-month-old female with recurrent pneumonia successfully treated with surgical intervention.
Int J Surg Case Rep
December 2024
Department of Pediatric Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Introduction: Achalasia, a rare esophageal disorder with an annual incidence of 0.11 per 100,000 in children, is characterized by impaired lower esophageal sphincter (LES) relaxation and peristalsis. Infantile cases are extremely uncommon and often linked to genetic conditions like Allgrove and Down syndrome.
View Article and Find Full Text PDFEffect of ultrasound-assisted extraction on phenolic profile, bio-accessibility, OVCAR-3, and SKOV-3 cytotoxicity in blackthorn (Prunus spinosa L.).
J Food Sci
December 2024
Faculty of Engineering, Department of Food Engineering, Trakya University, Edirne, Turkey.
This study aimed to examine the extraction of specific phenolic compounds from blackthorn using ultrasound-assisted extraction (UAE) and to evaluate the influence of UAE on the phenolic composition, bioaccessibility, and cytotoxic effect evaluated on ovarian cancer (OVCAR-3 and SKOV-3) and healthy (HaCaT) cell lines. The UAE parameters were optimized by modeling with the response surface method. Temperature, time, and ultrasound amplitude were utilized to determine the optimal extraction conditions.
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