AI Article Synopsis
- - Energy metabolism is crucial for survival, with mitochondria acting as the main energy producers in eukaryotic cells, but their role in cancer stem cells (CSCs) is not well understood.
- - The study compared various mitochondrial properties between lung cancer stem cells (LCSCs) and non-LCSCs, including amounts of mitochondria and mitochondrial DNA (mtDNA), membrane potential, and consumption of oxygen/glucose.
- - Key findings suggest that LCSCs exhibit unique mitochondrial characteristics—like specific mitochondrial distribution, lower mtDNA levels, and lower ATP and ROS levels—that could potentially serve as distinguishing indicators of these cells.
Article Abstract
Energy metabolism is the foundation of survival for all organisms, and mitochondria are the most important energy-supplying organelles in eukaryotic cells. However, the mitochondrial and energy/metabolism-related properties of cancer stem cells (CSCs), the stem cell-like subpopulation in tumor masses, remain unknown. In our study, we compared the masses of mitochondria and mitochondrial DNA (mtDNA), the mitochondrial membrane potential (Δψm), oxygen/glucose consumption, and the concentration of reactive oxygen species (ROS) and ATP between lung CSCs (LCSCs) and non-LCSCs. In addition, the change in features during differentiation was examined. Some mitochondrial and energy metabolism-related properties, such as perinuclear mitochondrial distribution, a lower quantity of mtDNA, higher Δψm, lower oxygen/glucose consumption, and lower intracellular concentrations of ROS and ATP, can be used as indicators of LCSCs.
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| http://dx.doi.org/10.1002/ijc.25944 | DOI Listing |
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