AI Article Synopsis
- Cytokine signaling via the JAK/STAT pathway influences key cellular functions like survival and movement, and although usually discussed in relation to inflammation, they also play a significant role in brain function.
- Using Drosophila, a simpler genetic model, researchers investigated the role of the cytokine Upd in memory formation, finding it is concentrated in the brain's memory center known as the mushroom bodies.
- The study demonstrated that Upd and its receptor, along with Drosophila's JAK and STAT proteins, are essential for long-term memory regarding unpleasant smells, while not necessary for other types of memories.
Article Abstract
Cytokine signaling through the JAK/STAT pathway regulates multiple cellular responses, including cell survival, differentiation, and motility. Although significant attention has been focused on the role of cytokines during inflammation and immunity, it has become clear that they are also implicated in normal brain function. However, because of the large number of different genes encoding cytokines and their receptors in mammals, the precise role of cytokines in brain physiology has been difficult to decipher. Here, we took advantage of Drosophila's being a genetically simpler model system to address the function of cytokines in memory formation. Expression analysis showed that the cytokine Upd is enriched in the Drosophila memory center, the mushroom bodies. Using tissue- and adult-specific expression of RNAi and dominant-negative proteins, we show that not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093528 | PMC |
| http://dx.doi.org/10.1073/pnas.1012919108 | DOI Listing |
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