Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Objective: This study was designed to demonstrate the frequency of sensitivity to European standard patch test allergens in patients with isolated itching of the external auditory canal (EAC).
Study Design: A prospective case-control study.
Methods: Fifty-six female patients with the complaint of recurrent EAC itching and 30 female controls without pruritis of the ears were patch-tested with 25 allergens of the European standard series.
Results: Twenty-four patients (25.5%) had one or more positive patch test reactions. In 21.4% of patients, nickel sulphate was the most frequent sensitizer, but there was no statistically significant difference in the nickel sensitization rate between patients and controls (p > .05). Sensitivity rates were much lower for the other allergens. There was no association between contact sensitivity to fragrances and to preservatives and patients with pruritis of the ears.
Conclusion: Our results do not demonstrate that most patients with pruritic ears probably suffer from allergic contact dermatitis.
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