The medical history and clinical oral examination of 125 patients taking psychopharmacologic agents as antipsychotic, antianxiety, antidepressant and hypnotic were studied and evaluated. From this study the following findings were assessed. Most patients taking antidepressant (63.4%) and sedative drugs (28.5%). The more frequent oral manifestations in patients who taking psychopharmacologic agents are the xerostomia (47.4%) and the materia alba of the tongue (25.4%). Finally, the limitations and the modifications in dental treatment are relative of kind and duration of receiving of psychopharmacologic agents and of their interaction with dental drugs.
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