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Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma.
Blood
March 2023
Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN.
Familial aggregation of Hodgkin lymphoma (HL) has been demonstrated in large population studies, pointing to genetic predisposition to this hematological malignancy. To understand the genetic variants associated with the development of HL, we performed whole genome sequencing on 234 individuals with and without HL from 36 pedigrees that had 2 or more first-degree relatives with HL. Our pedigree selection criteria also required at least 1 affected individual aged <21 years, with the median age at diagnosis of 21.
View Article and Find Full Text PDFIdentification of seven tumor-educated platelets RNAs for cancer diagnosis.
J Clin Lab Anal
June 2021
The First Affiliated Hospital and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, Cyrus Tang Medical Institute, State Key Laboratory of Radiation Medicine and Protection, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, National Clinical Research Center for Hematological Diseases, Soochow University, Suzhou, China.
Background: Tumor-educated platelets (TEPs) may enable blood-based cancer diagnosis. This study aimed to identify diagnostic TEPs genes involved in carcinogenesis.
Materials And Methods: The TEPs differentially expressed genes (DEGs) between healthy samples and early/advanced cancer samples were obtained using bioinformatics.
Identification of a Combined RNA Prognostic Signature in Adenocarcinoma of the Lung.
Med Sci Monit
May 2019
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
BACKGROUND Adenocarcinoma of the lung is a type of non-small cell lung cancer (NSCLC). Clinical outcome is associated with tumor grade, stage, and subtype. This study aimed to identify RNA expression profiles, including long noncoding RNA (lncRNA), microRNA (miRNA), and mRNA, associated with clinical outcome in adenocarcinoma of the lung using bioinformatics data.
View Article and Find Full Text PDFTwenty-gene-based prognostic model predicts lung adenocarcinoma survival.
Onco Targets Ther
June 2018
Department of Thoracic Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.
Introduction: Lung adenocarcinoma (LAC) accounts for more than a half of non-small cell lung cancer with high morbidity and mortality. Progression of treatment has not accelerated the improvement of its prognosis. Hence, it is an urgent need to develop novel biomarkers for its early diagnosis and treatment.
View Article and Find Full Text PDFCombined linkage and association analysis of classical Hodgkin lymphoma.
Oncotarget
April 2018
School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.
The heritability of classical Hodgkin lymphoma (cHL) has yet to be fully deciphered. We report a family with five members diagnosed with nodular sclerosis cHL. Genetic analysis of the family provided evidence of linkage at chromosomes 2q35-37, 3p14-22 and 21q22, with logarithm of odds score >2.
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