The keratocytes play a leading role in maintaining the normal transparent corneal structure, but also in repairing it, following various injuries. Knowledge of phenotype changes of these cells is important, both for explaining corneal pathology and for researching new therapy options.

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Alginates induce differentiation and expression of CXCR7 and CXCL12/SDF-1 in human keratinocytes--the role of calcium.

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Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, St. Olavs Hospital, N-7491 Trondheim, Norway.

Alginates from seaweed are used in chronic wound management, though the molecular and cellular effects of various alginate dressings are not well documented. We have developed ultrapure sodium-alginates from Pseudomonas fluorescens with different content and distribution of single guluronic acid (G) residues (0-45% G), and tested their biological activities on human primary keratinocytes (KCs). The alginates inhibited KC migration and induced expression of differentiation markers.

View Article and Find Full Text PDF

The keratocytes play a leading role in maintaining the normal transparent corneal structure, but also in repairing it, following various injuries. Knowledge of phenotype changes of these cells is important, both for explaining corneal pathology and for researching new therapy options.

View Article and Find Full Text PDF

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