AI Article Synopsis
- The study examined how high doses of ethanol affect the activity of enzymes involved in GABA metabolism in brain mitochondria during six stages of postnatal development.
- After administering a high dose of ethanol, the activity of these enzymes in various brain regions (cerebral cortex, cerebellum, hypothalamus, and brain stem) was observed to increase.
- Notably, GABA-T activity decreased significantly in the 10- and 21-day-old animals, whereas, in other developmental periods, its activity was found to increase.
Article Abstract
The activity of the enzymes of GABA- GDK and GABA-T metabolism in the brain mitochondria in 6 periods of postnatal development under the conditions of high dose of ethanol was studied. It has been revealed that after the impact of high dose of ethanol (3.5 g/kg of 25% solution, intraperitoneally) the enzymes' activities in initial mitochondrial fractions of cerebral cortex, cerebellum, hypothalamus and brain stem increases. The activity of GABA-T in 10- and 21-days animals significantly decreases, while in other periods on the contrary it increases.
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