The cirrhotic patients are at increased risk of infection greater than patients with other chronic diseases, due to differences in inflammatory and immune reactions. In cirrhotic patients with ascites, you must pay close attention to the prevention of complications such as hyponatremia, hepatorenal syndrome and spontaneous bacterial peritonitis SBP.The hospital mortality after an episode of SBP is 12-15% in the elderly, less than 10% in adults. Over 70% of patients with SBP belong to Class C Child-Pugh. Spontaneous bacterial peritonitis, the most common infection in cirrhosis, is characterized by a bacterial infection of ascites in the absence of conditions of intra-abdominal surgical relevance. After having described the pathogenesis, clinical and management of spontaneous bacterial peritonitis in elderly cirrhotic patients with ascites, the Authors stressed the most recent therapeutic measures and, particularly, the effectiveness of antibiotic treatment. An appropriate focus on the occurrence of complications is essential for life and survival of these patients.
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Tomography
December 2024
Department of Radiology, Nemours Children's Health, 1600 Rockland Rd., Wilmington, DE 19803, USA.
Evaluating altered mental status and suspected meningeal disorders in children often begins with imaging, typically before a lumbar puncture. The challenge is that meningeal enhancement is a common finding across a range of pathologies, making diagnosis complex. This review proposes a categorization of meningeal diseases based on their predominant imaging characteristics.
View Article and Find Full Text PDFPLoS Pathog
December 2024
Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Human pathogen Streptococcus pneumoniae forms multiple epigenetically and phenotypically distinct intra-populations by invertase PsrA-driven inversions of DNA methyltransferase hsdS genes in the colony opacity-determinant (cod) locus. As manifested by phase switch between opaque and transparent colonies, different genome methylation patterns or epigenomes confer pathogenesis-associated traits, but it is unknown how the pathogen controls the hsdS inversion orientations. Here, we report our finding of the SpxA1-TenA toxin-antitoxin (TA) system that regulates the orientations of hsdS inversions, and thereby bacterial epigenome and associated traits (e.
View Article and Find Full Text PDFCureus
November 2024
Department of Pediatrics, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, JPN.
The clinical manifestation of intracranial mycotic aneurysms (ICMAs), which are rare but carry high risks of rupture and early mortality, remains poorly understood. We present a case of an ICMA that rapidly developed and ruptured after the diagnosis of meningitis caused by (), which rarely causes bacterial meningitis. A 54-year-old man presented with a headache that worsened on coughing, without altered consciousness or vomiting.
View Article and Find Full Text PDFLuminescence
December 2024
Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
The present study was performed to synthesize eco-friendly nickel oxide nanoparticles (NiONPs) from the aqueous extract of Fissidens species (FS) and explore its biological activities. Phytochemicals, namely, alkaloids, flavonoids, sterols, tannins, proteins, carbohydrates and phenols, were present in the aqueous extract of Fissidens sp. The UV-Vis and FT-IR analyses of FS-NiONPs revealed a prominent peak at 392 nm, along with functional groups that facilitate the formation of FS-NiONPs.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Biol Lipids
December 2024
Department of Chemistry and Biochemistry, Villanova University, Villanova, PA 19085, USA. Electronic address:
An open reading frame from the actinobacterium Mycolicibacterium smegmatis annotated as a Prostaglandin H Synthase (PGHS) was expressed with an N-terminal (his) tag and purified to homogeneity. The enzyme has a monomeric molecular weight of 68.3 kD and exists as a dimer in the presence of nonionic detergent.
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