Susac's syndrome is an infrequent neurological disorder characterized by the clinical triad of encephalopathy, hearing loss, and branch retinal artery occlusions. Its pathophysiology is not entirely clear, although it is now thought that it is most probably an immune-mediated endotheliopathy that affects the microvasculature of the brain, retina, and inner ear. An early diagnosis is important as treatment can halt disease progression and prevent permanent disability.
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Clinical Characterization and Prognostic Risk Factors of Susac Syndrome: A Retrospective Multicenter Study.
Neurol Neuroimmunol Neuroinflamm
March 2025
The Faculty of Medical & Health Sciences, Tel Aviv University.
Background And Objectives: Susac syndrome (SuS) is a rare disorder characterized by encephalopathy, branch retinal artery occlusion, and sensorineural hearing loss, often accompanied by vertigo. Recent updates to diagnostic criteria and treatment guidelines have been made. This study examines clinical manifestations; disease activity; and risk factors of disability, dependency, and return to work in patients with SuS.
View Article and Find Full Text PDFBrain microstructural damage through serial diffusion tensor imaging and outcomes in Susac syndrome: A prospective cohort study.
Eur J Neurol
January 2025
Department of Internal Medicine, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Background: Susac syndrome (SuS) is a rare immune-mediated microangiopathy with potential disabling evolution. We aimed to analyze brain microstructural damage through diffusion tensor imaging (DTI) in SuS and determine its association with poor outcomes.
Method: CarESS study is a prospective multicenter national cohort study of patients with SuS.
Basal Ganglia Involvement in Susac Syndrome During Pregnancy.
Can J Neurol Sci
December 2024
Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada.
Gass plaques in Susac syndrome.
Eye (Lond)
November 2024
Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Integrated physiotherapy approach for susac syndrome: A comprehensive case study.
J Bodyw Mov Ther
October 2024
Rehabilitation Centre Život, Bleiburških Žrtava 49, Mostar, 88000, Bosnia and Herzegovina.
Introduction: Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss. This study presents the case of a patient undergoing intensive physiotherapy intervention following an injury, focusing on assessments such as volume and range of motion measurements, manual muscle tests, and pain intensity evaluations using various scales.
Case Description: The patient, aged 17, initially presented with severe limitations in mobility, diagnosed with Susac syndrome.
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