AI Article Synopsis
- FKBP52 and FKBP51, large molecular weight immunophilins, are primarily known for their roles in steroid hormone receptor complexes but also have significant regulatory functions in various cellular processes.
- Their genes, FKBP4 and FKBP5, are similar across chordates and their expression is affected by both genetic and epigenetic factors.
- Recent research highlights their involvement in the nervous system, reproduction, cancer, and the regulation of tau protein and microtubule assembly, as well as interactions with ion channel proteins from the TRPC subfamily.
Article Abstract
Best established as components of steroid hormone receptor complexes, it is now clear that the large molecular weight immunophilins, FKBP52 and FKBP51, play important regulatory roles elsewhere in the cell. This review outlines what is known about the organization of the genes, FKBP4 and FKBP5, respectively, encoding these proteins and describes their diverse actions in the nervous system, reproduction, and cancer. The organization of FKBP4 and FKBP5 is very similar among the chordates, and gene expression is influenced by both genetic and epigenetic mechanisms. Recent studies identifying roles of FKBP52 and FKBP51 in the regulation of the microtubule-associated protein tau and microtubule assembly are discussed, as is their interaction with and influence on the transient receptor potential canonical (TRPC) subfamily of ion channel proteins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156272 | PMC |
| http://dx.doi.org/10.1016/j.coph.2011.03.013 | DOI Listing |
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