AI Article Synopsis
- Oxysterols are oxidized derivatives of cholesterol that can indicate various health and environmental conditions through their presence in cells and tissues.
- This mini-review summarizes research findings on how different factors like reactive species and enzyme activity influence oxysterol formation both in vitro and in vivo.
- It also explores links between oxysterol levels and human diseases such as diabetes, as well as the role of oxidative stress in neurons related to pre-Parkinsonian conditions.
Article Abstract
Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.
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| http://dx.doi.org/10.1016/j.chemphyslip.2011.03.005 | DOI Listing |
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