Objective: To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.
Design: Case report.
Setting: Private assisted reproductive technology clinic in Japan.
Patient(s): A couple with male factor infertility due to Kartagener's syndrome.
Intervention(s): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline.
Main Outcome Measure(s): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI.
Result(s): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered.
Conclusion(s): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome.
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| http://dx.doi.org/10.1016/j.fertnstert.2011.03.074 | DOI Listing |
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