AI Article Synopsis
- The study aimed to establish reference data for atrial size and function in children and adolescents using cardiac MRI.
- A total of 115 healthy participants (ages 4.4 to 20.3) were examined to measure atrial volumes and their functional metrics, resulting in sex-specific findings, particularly in size variances between genders.
- The results indicated that boys generally exhibited larger atrial volumes and cyclic volume change, while girls demonstrated better emptying fractions, suggesting the need for tailored pediatric reference standards for clinical assessment and research.
Article Abstract
Purpose: To provide reference data for atrial size and function during childhood and adolescence by cardiac MR (CMR).
Materials And Methods: We prospectively examined 115 healthy children and adolescents (mean age, 12.4 ± 4.1 years; range, 4.4-20.3 years) by CMR using a stack of standard two-dimensional steady-state free-precession slices acquisition covering the whole heart in transverse plane. Maximal and minimal volumes of both atria and their respective calculated cyclic volume change (CVC) and emptying fraction (EMF) were determined and reference centile curves were computed (lambda-mu-sigma [LMS]-method).
Results: Gender differences were noted for atrial volumes and derived parameters. Maximal right atrial (RA) volume for girls was 53.3 ± 11.8 mL/m(2) and 58.1 ± 15.7 for boys (P = 0.064), minimal RA volume for girls/boys was 23.2 ± 6.2/27.0 ± 7.9 mL/m(2) (P = 0.004). Maximal left atrial (LA) volume for girls/boys was 44.2 ± 8.7/46.7 ± 10.1 mL/m(2) (P = 0.143) and minimal LA volume for girls/boys was 19.2 ± 3.9/21.5 ± 5.1 mL/m(2) (P = 0.009). For both atria, CVC was higher for boys, but EMF higher for girls. Percentiles of RA/LA volumes showed steeper increase in boys than in girls, who in fact showed a plateau after age 14.
Conclusion: Pediatric sex-specific reference centiles are provided to improve clinical interpretation and facilitate future research involving CMR-derived atrial function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmri.22521 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Does pubertal stage mediate the association between family environment and structure and function of the amygdala-mPFC circuit? A replication study of the longitudinal ABCD cohort.
Dev Cogn Neurosci
August 2022
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Psychosocial acceleration theory suggests that early stress accelerates pubertal development. Using half of the baseline Adolescent Brain and Cognitive Development (ABCD) cohort, Thijssen et al. (2020) provide support that accelerated puberty following stressful family environments may promote neurodevelopment.
View Article and Find Full Text PDFThe associations between weight-related anthropometrics during childhood and lung function in late childhood: a retrospective cohort study.
BMC Pulm Med
January 2018
Department of Paediatrics, Stavanger University Hospital, POB 8100, N-4068, Stavanger, Norway.
Background: An association between body weight in childhood and subsequent lung function and asthma has been suggested, but few longitudinal studies exist. Our aim was to explore whether weight-related anthropometric measurements through childhood were associated with lung function in late childhood.
Methods: From an original nested case-control study, a cohort study was conducted, where lung function was measured in 463 children aged 12.
Reference values for atrial size and function in children and young adults by cardiac MR: a study of the German competence network congenital heart defects.
J Magn Reson Imaging
May 2011
Hannover Medical School, Department of Heart, Thoracic, Transplantation, and Vascular Surgery, Germany.
Article Synopsis
- The study aimed to establish reference data for atrial size and function in children and adolescents using cardiac MRI.
- A total of 115 healthy participants (ages 4.4 to 20.3) were examined to measure atrial volumes and their functional metrics, resulting in sex-specific findings, particularly in size variances between genders.
- The results indicated that boys generally exhibited larger atrial volumes and cyclic volume change, while girls demonstrated better emptying fractions, suggesting the need for tailored pediatric reference standards for clinical assessment and research.
Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests.
Thorax
April 2007
Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, UCL, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Background: Lung clearance index (LCI), a measure of ventilation inhomogeneity derived from the multiple-breath inert gas washout (MBW) technique, has been shown to detect abnormal lung function more readily than spirometry in preschool children with cystic fibrosis, but whether this holds true during infancy is unknown.
Objectives: To compare the extent to which parameters derived from the MBW and the raised lung volume rapid thoraco-abdominal compression (RVRTC) techniques identify diminished airway function in infants with cystic fibrosis when compared with healthy controls.
Methods: Measurements were performed during quiet sleep, with the tidal breathing MBW technique being performed before the forced expiratory manoeuvres.
Sex differences in cognitive functioning in velocardiofacial syndrome (VCFS).
Dev Neuropsychol
January 2006
Department of Psychiatry and Behavioral Sciences, State University of New York-Upstate Medical University, Syracuse, NY 13210, USA.
Sex differences in cognitive functioning were investigated in children with velocardiofacial syndrome (VCFS), a genetic defect caused by a microdeletion on chromosome 22q.11. The study population consisted of six groups: 50 boys with VCFS (M = 11.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!