[Effect of diazepam on mitochondrial respiration].

C R Seances Soc Biol Fil

Université de Pavie, Faculté de Médecine, Dépt. Biochimie, Italie.

Published: May 1991

Our hypothesis that the strong effects of neutropic drugs on nervous system have hidden more widespread effects on all tissues and cells, is collecting evidences in our laboratory. We have essayed in vitro benzodiazepines on liver rat mitochondria. The present work deals with experiments on diazepam: it depresses the respiration coupled to phorphorylation in mitochondria having a good respiratory control; so respiratory control too is depressed. Also P/O ratio is lowered.

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