This is Sudan's first cross sectional exploratory study aimed to analyze the appropriateness of prescriptions written in different health settings in Wad Medani, Sudan. Two pretested questionnaires were used to collect information about the possible causes of medication errors from randomly selected practicing physicians and pharmacists. The sample consisted of 2000 prescriptions collected in the period of August and September 2009. There were statistically significant differences between legibility of printed and handwritten prescriptions (p < 0.001), of all prescriptions 43.8% was not accompanied by instructions to the patients and 14% contained potential interactions with different degrees of seriousness, ranging from minor 1.8%, moderate 8.4% and severe 3.9%. According to the standard classifications of prescription writing, only one prescription (0.1%) was considered ideal with no error encountered, 12.2% of prescriptions contained errors being potentially serious to the patients, 17.8% showed errors of major importance, 6.9% had errors of minor importance and 10.5% contained trivial errors. While of the prescriptions 52.6% were free from errors but they were incomplete, something that could lead to serious patients' harm. The study identified a range of weaknesses in the prescribing phase and proposed a set of recommendations encouraging physicians and pharmacists to work together to avoid such errors.
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http://dx.doi.org/10.3233/JRS-2011-0520 | DOI Listing |
Adv Sci (Weinh)
January 2025
Department of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA.
Biopharmaceuticals are the fastest-growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which significantly extends shelf-life. Unfortunately, these excipients are themselves unstable, oxidizing rapidly into 100s of distinct compounds, some of which cause severe adverse events in patients.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
January 2025
College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
The accurate non-invasive detection and estimation of central aortic pressure waveforms (CAPW) are crucial for reliable treatments of cardiovascular system diseases. But the accuracy and practicality of current estimation methods need to be improved. Our study combines a meta-learning neural network and a physics-driven method to accurately estimate CAPW based on personalized physiological indicators.
View Article and Find Full Text PDFFEBS J
January 2025
The FEBS Journal Editorial Office, Cambridge, UK.
The FEBS Journal publishes primary papers as well as reviews in the molecular life sciences relating to the molecules and mechanisms underpinning biological processes. Editor-in-Chief Seamus Martin shares some thoughts on the nature of conducting research, some highlights of the past year at the journal, and what is in store for 2025.
View Article and Find Full Text PDFPostgrad Med J
January 2025
Department of Pediatric Metabolic Diseases, University of Health Sciences, Ankara Etlik City Hospital, Ankara 06170, Turkey.
Metabolism is the name given to all of the chemical reactions in the cell involving thousands of proteins, including enzymes, receptors, and transporters. Inborn errors of metabolism (IEM) are caused by defects in the production and breakdown of proteins, fats, and carbohydrates. Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules, ⁓19-25 nucleotides long, hairpin-shaped, produced from DNA.
View Article and Find Full Text PDFPhysiother Res Int
January 2025
Department of Physiotherapy, Centro Universitário FUNCESI, Itabira, Brazil.
Background And Purpose: To develop a new test to assess the motor coordination of the upper limbs, and to investigate the test-retest and inter-rater reliability, construct validity, standard error of measurement (SEM), minimum detectable change (MDC), and the reference values.
Methods: The Upper Extremity Motor Coordination Test (UEMOCOT)was applied for 20 s, with the individual touching two targets (one right and one left) as quickly as possible, first with the hand (manual task) and then with the index finger (finger task). To test-retest reliability, the UEMOCOT was administered two times.
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