Acanthamoeba granulomatous encephalitis generally develops as a result of haematogenous spread, but it is unclear how circulating amoebae enter the central nervous system (CNS) and cause inflammation. At present, the mechanisms which Acanthamoeba use to invade this incredibly well-protected area of the CNS and produce infection are not well understood. In this paper, we propose two key virulence factors: mannose-binding protein and extracellular serine proteases as key players in Acanthamoeba traversal of the blood-brain barrier leading to neuronal injury. Both molecules should provide excellent opportunities as potential targets in the rational development of therapeutic interventions against Acanthamoeba encephalitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pt.2011.01.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
-Containing Vacuole within : Isolation and Proteomic Characterization.
Microorganisms
September 2024
Department of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
is a highly infectious gram-negative bacterium that causes tularemia in humans and animals. It can survive and multiply in a variety of cells, including macrophages, dendritic cells, amoebae, and arthropod-derived cells. However, the intracellular life cycle of a bacterium varies depending on the cell type.
View Article and Find Full Text PDFUsing Acanthamoeba spp. as a cell model to evaluate Leishmania infections.
PLoS Negl Trop Dis
October 2024
Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil.
Article Synopsis
- Leishmaniasis is a serious disease that's hard to control because there are no vaccines, the medicines can be toxic, and some parasites have become super strong against treatments.
- Researchers want to find a simple way to study how Leishmania interacts with cells, and they think Acanthamoeba, tiny organisms similar to the cells Leishmania infects, could help.
- The study showed that Leishmania can infect and multiply inside Acanthamoeba without harming them, which means Acanthamoeba might be useful for understanding Leishmania infections better.
Adaptation to an amoeba host drives selection of virulence-associated traits and genetic variation in saprotrophic .
Front Cell Infect Microbiol
April 2024
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Amoebae are micropredators that play an important role in controlling fungal populations in ecosystems. However, the interaction between fungi and their amoebic predators suggests that the pressure from predatory selection can significantly influence the development of fungal virulence and evolutionary processes. Thus, the purpose of this study was to investigate the adaptation of saprotrophic strains during their interactions with .
View Article and Find Full Text PDFCerebrospinal fluid inflammatory cytokine profiles of patients with neurotropic parasitic infections.
Trop Biomed
December 2023
Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India.
The pathogenesis of chronic parasitic central nervous system (CNS) infections, including granulomatous amoebic meningoencephalitis (GAE), cerebral toxoplasmosis (CT), and neurocysticercosis (NCC), is primarily due to an inflammatory host reaction to the parasite. Inflammatory cytokines produced by invading T cells, monocytes, and CNS resident cells lead to neuroinflammation which underlie the immunopathology of these infections. Immune molecules, especially cytokines, can therefore emerge as potential biomarker(s) of CNS parasitic infections.
View Article and Find Full Text PDFA one health approach versus Acanthamoeba castellanii, a potential host for Morganella morganii.
Int Microbiol
November 2022
Department of Clinical Sciences, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Acanthamoeba castellanii, known as the "Trojan horse of the microbial world," is known to host a variety of microorganisms including viruses, yeasts, protists, and bacteria. Acanthamoeba can act as a vector and may aid in the transmission of various bacterial pathogens to potential hosts and are found in a variety of places, thus impacting the health of humans, animals, and the environment. These are interconnected in a system known as "one health.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!