Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.medcli.2011.02.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High Prevalence of Anti-Prothrombin IgM and IgG Autoantibodies in Women With Unexplained Recurrent Pregnancy Loss.
Reprod Sci
December 2024
Faculté des Sciences de Tunis, El Manar University, Tunis, Tunisia.
Article Synopsis
- The study explored the link between anti-prothrombin IgM and IgG antibodies and recurrent pregnancy loss (RPL) among 207 Lebanese women with RPL compared to 179 controls.
- Results showed that women with RPL had significantly higher levels of these antibodies, indicating they are associated with an increased risk of RPL.
- The findings support the need for screening for anti-prothrombin antibodies in women experiencing unexplained RPL to help improve treatment and management strategies.
The (reverse) paradox of lupus anticoagulant: A case report.
Lupus
October 2024
Department of Rheumatology, Max Super Speciality Hospital, New Delhi, India.
Article Synopsis
- Systemic Lupus Erythematosus (SLE) often coexists with antiphospholipid syndrome, leading to blood clotting issues or complications in pregnancy, as illustrated by a case of a 7-year-old girl experiencing fever, bleeding, and thrombophlebitis.
- The child presented with symptoms like gum bleeding, small skin lesions, and abnormal blood coagulation tests, prompting further investigation for an autoimmune disorder.
- Ultimately, she was diagnosed with Systemic Lupus Erythematosus and Lupus Anticoagulant Hypoprothrombinemia Syndrome after confirming the presence of specific antibodies and coagulation abnormalities.
Phosphatidylserine-Dependent Anti-prothrombin Antibodies as a Key Predictor for Systemic Lupus Erythematosus in Patients with Primary Antiphospholipid Syndrome: A retrospective longitudinal cohort study.
Mod Rheumatol
August 2024
Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Objectives: Primary antiphospholipid syndrome (PAPS) is an autoimmune disorder characterized by thrombosis and pregnancy morbidity. Although PAPS is distinct from systemic lupus erythematosus (SLE), the two conditions share clinical features and susceptibility genes. Progression from PAPS to SLE is well-recognized.
View Article and Find Full Text PDFInterference of lupus anticoagulant causing antiprothrombin and anti-beta-2-glycoprotein I antibodies on international normalized ratio measurements: comparative analysis of international normalized ratio methods.
Res Pract Thromb Haemost
July 2024
Department of Clinical Chemistry, Meander Medical Centre, Amersfoort, the Netherlands.
Background: Life-long vitamin K antagonist (VKA) therapy is recommended as a standard of care in antiphospholipid syndrome (APS) patients with thrombosis. Concerns have been raised about the validity of international normalized ratio (INR) measurements in lupus anticoagulant (LA)-positive APS patients because LA may interfere with phospholipid-dependent coagulation tests and could elevate INR measurements.
Objectives: Here, we aimed to determine the interference of antigen-specific monoclonal and isolated patient antibodies with LA activity on INR measurements.
Understanding the difference between type I and type II antiprothrombin antibodies and their effect on activated protein C resistance.
J Thromb Haemost
October 2024
Thrombosis Research Laboratory, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Padua, Italy; Arianna Foundation on Anticoagulation, Bologna, Italy. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!