AI Article Synopsis
- A double-blind trial involving 45 patients compared the effects of sulfentanil, fentanyl, and morphine as narcotic supplements during anesthesia.
- Morphine was found to have a longer duration of effect compared to fentanyl and sulfentanil, which had similar durations for the initial doses.
- Later doses of fentanyl showed increased effects likely due to cumulation, a phenomenon not observed with sulfentanil.
Article Abstract
In a double-blind trial, in a total of 45 patients, sulfentanil was compared with fentanyl and morphine in equipotent doses, as a narcotic supplement to anesthesia. Initially, morphine was shown to have a significantly longer duration of effect than fentanyl and sulfentanil, which for the first 3 doses had similar durations of action to each other. Later doses of fentanyl, however, had an extended effect, presumably because of cumulation. This was not seen with sulfentanil.
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