Simulation of lamellipodial fragments.

J Math Biol

Faculty of Mathematics, University of Vienna, Nordbergstrasse 15/C/7, 1090, Vienna, Austria.

Published: February 2012

AI Article Synopsis

  • A steepest descent method is created for a model that describes how the actin cytoskeleton behaves in the lamellipodia of living cells.
  • The method serves as a numerical approach to simulate experiments where a piece of a lamellipodium is manipulated by a pipette.
  • This simulation helps understand how the shape and position of the lamellipodial fragment change in response to external forces.

Article Abstract

A steepest descent approximation scheme is derived for a recently developed model for the dynamics of the actin cytoskeleton in the lamellipodia of living cells. The scheme is used as a numerical method for the simulation of thought experiments, where a lamellipodial fragment is pushed by a pipette, and subsequently changes its shape and position.

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http://dx.doi.org/10.1007/s00285-011-0421-9DOI Listing

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