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Undescribed cytotoxic butenolides; asperterreunolides A-E, isolated from endophytic fungus Aspergillus terreus derived from Artemisia arborescens L. supported with in silico study.
Phytochemistry
December 2024
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA. Electronic address:
Article Synopsis
- The ethyl acetate extract from the endophytic fungus Aspergillus terreus found in Artemisia arborescens L. led to the discovery of five new compounds, asperterreunolides A-E, along with a known metabolite, butyrolactone IV.
- Using advanced spectroscopic techniques, the researchers determined the structures and the absolute configurations of these metabolites.
- All isolated compounds exhibited significant cytotoxic effects against certain cancer cell lines, and molecular docking studies suggested their potential mechanism of action as inhibitors of type IIA topoisomerase.
Cognitive-enhancing effect of fruit on scopolamine-induced cognitive impairment in rats: metabolite profiling, , and investigations.
RSC Adv
December 2024
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University Cairo 11562 Egypt
Many plants are reported to enhance cognition in amnesic-animal models. The metabolite profile of fruit methanolic extract (CDFME) was characterized by LC-QTOF-MS/MS, and its total phenolics content (TPC) and total flavonoids content (TFC) were determined. In parallel, its cognitive-enhancing effect on scopolamine (SCOP)-induced AD in rats was evaluated.
View Article and Find Full Text PDFNon-healing extraction socket: a diagnostic challenge for general dental practitioners.
Br Dent J
December 2024
UCL Eastman Dental Institute, University College London, United Kingdom.
Introduction In the UK, more than 18 million extractions are performed annually. Healing after extraction is often uneventful, but there are rare cases where weeks or months pass and an extraction socket does not heal.Aim The aim of this study is to provide a review of cases in which a non-healing extraction socket is attributed to a serious systemic disease or malignancy, or an adverse consequence of systemic therapy.
View Article and Find Full Text PDFCOVID-19 vaccine knowledge and acceptance among the Libyan population: A cross-sectional study.
Hum Vaccin Immunother
December 2025
Faculty of Medicine, Libyan International Medical University, Benghazi, Libya.
We aim to identify Libyans' knowledge, attitudes, and acceptance regarding the COVID-19 vaccine. A cross-sectional survey was electronically distributed to the Libyan population aged 18 and older between May and September 2023. The questionnaire had three sections: socio-demographics, COVID-19 vaccination and infection, and knowledge and attitudes toward the COVID-19 vaccine.
View Article and Find Full Text PDFMeasuring personality in Libyan Arabs: validating the big five aspect scale with 10 factors domain.
BMC Psychol
December 2024
Psychology department, Humanities and social sciences research center (HSSRC), College of Humanities and sciences, Ajman, UAE.
Research has developed the Big-Five Aspect Scale (BFAS), supporting a five-domain model that includes 10 related aspects. In Arabic societies, there is currently a lack of validation evidence for a scale with these 10 aspects. Thus, this study develops and examines the psychometric properties of the short version of the BFAS (BFAS-SV) within Libyan Arab adults.
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