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A simple HPLC method for the determination of plasma progesterone levels in the third trimester of human pregnancy.
Lab Med
December 2024
Atatürk University, Faculty of Medicine, Department of Obstetrics and Gynecology, Erzurum, Turkey.
Progesterone is a steroid hormone primarily associated with pregnancy. A simple, rapid, and reliable high-performance liquid chromatography (HPLC) method has been developed and validated for the quantification of progesterone in human plasma. The method consists of a simple liquid-liquid extraction of progesterone and internal standard (estriol) from human plasma using a mixture of hexane and diethyl ether.
View Article and Find Full Text PDFDiagnosing american bison pregnancy during its two last trimesters: Comparison between rectal palpation associated with ultrasonography and hormonal assays in serum or in feces.
Anim Reprod Sci
January 2025
Theriogenology unit, FARAH Comparative Veterinary Medicine, Liège University, Belgium. Electronic address:
The study aimed to propose sensitive, specific and easy pregnancy diagnosis for American Bison. Trans-rectal Palpation and Ultrasonography (TRPUS), concentration of Pregnancy Associated Glycoproteins (PAG), Progesterone (P4), Estrone (E1), Estrone-Sulfate (E1S) in serum and P4 and E1S in feces were compared. Immunoassay was used for PAG, whereas steroids were assayed using Liquid Chromatography coupled to Mass Spectrometry.
View Article and Find Full Text PDFAntithyroglobulin and Antiperoxidase Antibodies Can Negatively Influence Pregnancy Outcomes by Disturbing the Placentation Process and Triggering an Imbalance in Placental Angiogenic Factors.
Biomedicines
November 2024
Department of Endocrinology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
: Thyroid autoimmunity (TAI) affects about 15% of women of reproductive age and can negatively affect pregnancy outcomes. One possible mechanism for pregnancy complications can be attributed to a disturbed process of placentation caused by thyroid antibodies. To test this hypothesis, placental hormones and angiogenic factors in pregnant women with TAI were evaluated.
View Article and Find Full Text PDFHormonal biomarkers and preterm birth: insights from a study of pregnant women in Lahore, Pakistan.
Endocr Regul
January 2024
Institute of Zoology, University of the Punjab, Lahore, Punjab, Pakistan.
Article Synopsis
- Progesterone and its metabolites play a crucial role in maintaining pregnancy and influencing myometrial contractility, with SHBG serving as a biomarker for premature birth.
- The study involving 500 pregnant women found that low levels of vitamin D, SHBG, and certain progesterone metabolites were prevalent in those at risk for preterm birth, suggesting these factors could help predict such risks early on.
Safety of herbal medicines used in early gestations among the Chinese population: A population-based cohort study.
Phytomedicine
December 2024
General Practice Medical Center, Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, 610041, China; Sichuan Center of Technology Innovation for Real World Data, Chengdu, 610041, China; West China School of Public Health, Sichuan University, Chengdu, 610041, China. Electronic address:
Background: Herbal medicines have a long history of use for pregnant women around the world. However, their use in the early pregnancy is often questioned in terms of safety on offspring.
Purpose: To investigate whether herbal medicines used at early pregnancy are associated with an increased risk of birth defects.
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