Introduction: There is a paucity of data regarding efficacy and safety of high dose (>8mg/kg/day) daptomycin.
Material And Methods: This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data.
Results: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them.
Conclusions: High dose daptomycin shows good efficacy without concerns about toxicity.
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| http://dx.doi.org/10.1016/j.eimc.2011.02.012 | DOI Listing |
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