Background: Our objective was to assess the impact of screening and identifying methicillin-resistant Staphylococcus aureus (MRSA) carriers as a single measure in 4 intensive care units (ICUs).
Methods: An evaluative study including two 6-month periods was conducted prospectively. The evaluation concerned the hand hygiene compliance (HHC) for contacts with MRSA carriers versus contacts with noncarriers (comparison C1, main objective) and for a period of absence of identification (P1) versus a period of identification (P2) (comparison C2) and MRSA cross transmission (P1 vs P2) (comparison C3) measured with 2 indicators.
Results: Overall, 1326 opportunities of hand hygiene were observed. Concerning C1, the HHC for contacts with MRSA carriers was 42.5% versus 43.1% for contacts with noncarriers (not significant). This absence of difference was recorded whatever the ICU specialty, the category of personnel, and the nature of contacts. Concerning C2, the HHC in P1 was 44.8% versus 48.5% in P2 (not significant). Concerning C3, no significant difference was identified between the 2 periods.
Conclusion: We did not identify any advantage by using screening and identifying MRSA carriers in those 4 ICUs in which no specific strategy of additional contact measures was implemented for MRSA carriers.
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http://dx.doi.org/10.1016/j.ajic.2010.10.029 | DOI Listing |
Int J Med Microbiol
December 2024
Institute of Medical Microbiology, University Hospital Münster, Münster, Germany; Masanga Medical Research Unit, Masanga Hospital, Masanga, Sierra Leone.
Background: Nasopharyngeal colonization with Staphylococcus aureus is a risk factor for subsequent infection. Isolates from colonization can therefore provide important information on virulence factors and antimicrobial resistance when data from clinical isolates are lacking. The aim of this study was to assess colonization rates, resistance patterns and selected virulence factors of S.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:
The development of functional hydrogel dressings with robust mechanical properties has posed a significant challenge in expediting the healing process of MRSA-infected wounds. To address this, a composite hydrogel, comprising carboxylated soybean cellulose nanocrystals (CNCs), poly(N-isopropyl acrylamide) (PNIPAM), dimethyl diallyl ammonium chloride (PDADMAC), and kaolin (CN/P-K) was synthesized. CNCs served to stabilize the interpenetrating polymer networks of PNIPAM and PDADMAC through hydrogen bonding and electrostatic interactions, respectively, while the kaolin interlayer improved the material toughness.
View Article and Find Full Text PDFACS Appl Bio Mater
December 2024
Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4300, South Africa.
Bacterial infections pose an increasingly worrisome threat to the health of humankind, with antibiotic resistance contributing significantly to this burden. With current conventional antibiotics perpetuating the problem, and a paucity in developing antibiotics, drug delivery systems incorporating nanotechnology appear promising. As such, a dual enzyme-responsive multifunctional nanostructured lipid carrier (NLC) incorporating farnesol (FAN) and triglycerol monostearate (TGMS), was conceptualized for the codelivery of vancomycin (VCM) and antimicrobial peptide (AMP) to enhance the antibacterial activity of VCM.
View Article and Find Full Text PDFInt J Pharm
December 2024
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza, Egypt.
Oleic acid liposomes (OALs) are novel vesicular carriers ofunsaturated fatty acids and their corresponding ionized species, arranged within an enclosed lipid bilayer. This study aimed to encapsulate moxifloxacin HCl (MOX), a broad-spectrum antibacterial drug into OALs for effective treatment of Methicillin-resistant Staphylococcus aureus (MRSA) infection through topical application. Various OALs were formulatedby combining varied quantities of phosphatidylcholine (PC), oleic acid (OA), and cholesterol (CH) with 50 mg of MOX.
View Article and Find Full Text PDFJ Clin Med
November 2024
Independent Public Health Care Center RM-MEDITRANS Emergency Station and Sanitary Transport in Siedlce, 08-110 Siedlce, Poland.
An ambulance used by an emergency medical service team is the workplace of specialised medical personnel, providing daily transportation for patients in life-threatening conditions, from all walks of life, with numerous diseases and injuries. MRSA (methicillin-resistant ) strains are classified as Gram-positive cocci, characterised primarily by their multidrug resistance. Infections caused by have a low treatment success rate and are associated with persistent carrier state.
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