Aim: To compare the qualitative and quantitative AgNOR scores per nucleus of histological grades.
Material And Methods: Thirty-five needle biopsies from patients with prostate cancer (PC) aged 60 to 75 years were investigated. The morphologic parameters examined on histological specimens were: microscopic patterns, Gleason's histological grades (GLG), and AgNOR scores by automated image analyzer and quantitative AgNOR counts according to the classification, fine granules, large granules, and total granule counts.
Results: Our data suggest a significant correlation between GLG, AgNOR scores, and the percentage of both AgNOR fine and large granules. In HPIN, AgNOR count was evidently higher (5.56) as compared to normal acinar epithelium, slightly exceeding the level found in well-differentiated carcinoma (5.3). In our cases, the highest AgNOR counts were found in poorly differentiated carcinomas (9.81). AgNOR density in ductal carcinomas (7.61) was close to that in moderately differentiated carcinomas (7.35).
Conclusion: This simple method may aid diagnostic judgement when interpreting needle biopsies of malignancy and act as a prognostic marker useful for identifying PC of low and high malignancy.
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