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A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks of in ICUs.
Microorganisms
December 2024
Department of Chest Medicine, Show Chwan Memorial Hospital, Changhua 500, Taiwan.
, a major opportunistic pathogen, causes severe infections in both community and healthcare settings, especially in intensive care units (ICUs), where multidrug-resistant (MDR) strains, such as carbapenem-resistant (CRKP), pose significant treatment challenges. The rise in hypervirulent (hvKP) with enhanced virulence factors complicates management further. The ST11 clone, prevalent in China, exhibits both resistance and virulence traits, contributing to hospital outbreaks.
View Article and Find Full Text PDFMultidrug-Resistant Strains in a Hospital: Phylogenetic Analysis to Investigate Local Epidemiology.
Microorganisms
December 2024
Operative Research Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy.
Multidrug-resistant is a significant healthcare challenge that particularly affects vulnerable patients through opportunistic nosocomial infections. Surveillance is crucial for monitoring the prevalence of these infections. Eighty-four KPC strains (2019-2022) were collected from patients admitted in Fondazione Policlinico Universitario Campus Bio-Medico.
View Article and Find Full Text PDFAntibiotic Resistance Trends in Carbapenem-Resistant Gram-Negative Pathogens and Eight-Year Surveillance of XDR Bloodstream Infections in a Western Greece Tertiary Hospital.
Pathogens
December 2024
Department of Internal Medicine, University Hospital of Patras, 265 04 Patras, Greece.
: The increased prevalence of antibiotic resistance among Gram-negative bacteria presents a severe public health challenge, leading to increased mortality rates, prolonged hospital stays, and higher medical costs. In Greece, the issue of multidrug-resistant Gram-negative bacteria is particularly alarming, exacerbated by overuse of antibiotics and inadequate infection control measures. This study aimed to detect the prevalence of extensively drug-resistant (XDR) Gram-negative bacteria in a tertiary hospital in Western Greece over the last eight years from 2016 to 2023.
View Article and Find Full Text PDFRetrospective Case-Control Study of Risk Factors for Carbapenem-Resistant Infection in Children in China.
Pathogens
December 2024
Pediatric Intensive Care Unit, The Second Hospital of Hebei Medical University, Shijiazhuang 050050, China.
This study aims to investigate the risk factors for infection and mortality associated with carbapenem-resistant (CRKP) in hospitalized children, with the goal of providing valuable insights for the prevention and treatment of these bacterial infections. A retrospective case-control study was conducted, including 153 cases of carbapenem-sensitive infection in children and 49 cases of CRKP infection. Among the CRKP cases, 40 children survived and nine died.
View Article and Find Full Text PDFHigh-Risk Lineages of Hybrid Plasmids Carrying Virulence and Carbapenemase Genes.
Antibiotics (Basel)
December 2024
Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg 197022, Russia.
Carbapenem-resistant (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant () and () isolated from Russian hospitals. : We performed short- and long-read whole-genome sequencing of 53 clinical isolates (48 and 5 ) attributed to 15 genetic lineages and collected from 21 hospitals across nine Russian cities between 2016 and 2022.
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