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- Ferroptosis is a form of cell death linked to iron and lipid damage, showing potential for cancer treatment, particularly involving lipid peroxidation of specific fatty acids.
- GPX4 normally prevents ferroptosis by converting harmful lipid hydroperoxides into less harmful forms, making it a potential drug target whose sensitivity is not well understood.
- Research indicates that cancer cells cultured in 3D conditions produce fewer polyunsaturated fatty acids and more monounsaturated fatty acids, which can help them resist ferroptosis and reduce the effectiveness of GPX4 inhibitors.
ASYMMETRIC LEAVES1 promotes leaf hyponasty in Arabidopsis by light-mediated auxin signaling.
Plant Physiol
December 2024
Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea.
Article Synopsis
- Balancing growth and environmental responses is vital for plant fitness, especially in shaded conditions which lead to morphological changes like hypocotyl growth and leaf hyponasty due to altered light quality and auxin levels.
- The ASYMMETRIC LEAVES1 (AS1) gene in Arabidopsis is shown to enhance leaf hyponasty by regulating auxin biosynthesis and transport, promoting cell elongation in response to shading.
- AS1 interacts with specific proteins and affects the expression of key genes related to auxin, suggesting it plays an essential role in how plants adapt to their light environment.
High Thickness Tolerance in All-Polymer-Based Organic Photovoltaics Enables Efficient and Stable In-Door Operation.
Adv Sci (Weinh)
November 2024
Department of Physics and Centre for Processable Electronics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK.
Organic photovoltaics (OPVs) have great potential to drive low-power consumption electronic devices under indoor light due to their highly tunable optoelectronic properties. Thick devices (>300 nm photo-active junctions) are desirable to maximize photocurrent and to manufacture large-scale modules via solution-processing. However, thick devices usually suffer from severe charge recombination, deteriorating device performances.
View Article and Find Full Text PDFCorrelation with Apoptosis Process through RNA-Seq Data Analysis of Hep3B Hepatocellular Carcinoma Cells Treated with Extract (GLE).
Int J Mol Sci
August 2024
Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa, Jinju 52828, Republic of Korea.
is a perennial herb found in coastal sand dunes throughout East Asia. This herb has been reported to have hepatoprotective, immunomodulatory, antioxidant, antibacterial, antifungal, anti-inflammatory, and anticancer activities. It may be effective against hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFA florigen-expressing subpopulation of companion cells expresses other small proteins and reveals a nitrogen-sensitive repressor.
bioRxiv
August 2024
Department of Biology, University of Washington, Seattle, Washington, 98195, USA.
The precise onset of flowering is crucial to ensure successful plant reproduction. The gene () encodes florigen, a mobile signal produced in leaves that initiates flowering at the shoot apical meristem. In response to seasonal changes, is induced in phloem companion cells located in distal leaf regions.
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