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Risk-stratification for treatment de-intensification in WNT-pathway medulloblastoma: finding the optimal balance between survival and quality of survivorship.
Expert Rev Anticancer Ther
July 2024
Department of Pediatric Oncology, ACTREC/TMH, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, India.
Article Synopsis
- Advances in molecular biology have categorized medulloblastoma into four subgroups (WNT, SHH, Group 3, and Group 4), impacting risk assessments and treatment strategies based on patient age and tumor characteristics.
- Traditional risk factors indicated that children over 3 years with minimal residual tumors have a high chance of long-term survival, while younger patients with larger, metastatic tumors face significantly lower survival rates.
- Current treatment approaches involve maximal tumor removal followed by tailored radio(chemo)therapy, aiming to improve survival rates while reducing treatment-related side effects, with ongoing research focused on optimizing risk stratification in specific subgroups.
Continued use of Warfarin in lower dose has safe maternal and neonatal outcomes in pregnant women with Prosthetic Heart Valves.
Pak J Med Sci
January 2021
Anjum Jalal, FRCS-CTh. Professor of Cardiac Surgery, Executive Director, Faisalabad Institute of Cardiology, Faisalabad, Pakistan.
Background And Objective: There has been concerns regarding the safety of Warfarin in pregnant females due to its teratogenic potential. At the same time warfarin provides best anticoagulation in patients with prosthetic valves. Various dosage regimes have been tried to strike a balance between safety of mother and the avoidance of congenital anomalies in the newborn.
View Article and Find Full Text PDFThe causes of spatiotemporal variations in erupted fluxes and compositions along a volcanic arc.
Nat Commun
March 2019
College of Earth, Ocean, & Atmospheric Sciences, Oregon State University, Corvallis, OR, USA.
Decades of study on volcanic arcs have provided insight into the overarching processes that control magmatism, and how these processes manifest at individual volcanoes. However, the causes of ubiquitous and dramatic intra-arc variations in volcanic flux and composition remain largely unresolved. Investigating such arc-scale issues requires greater quantitative comparison of geophysical and geochemical data, linked through sets of common intensive variables.
View Article and Find Full Text PDFDisaster medicine and response: Optimizing life-saving potential.
Am J Disaster Med
April 2019
Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.
Background: Natural and technological mass disasters strike densely populated areas on a regular basis, causing ever growing numbers of deaths and injured, economical losses, social problems, and damage to the environment.
Objective Of The Review: This review aims to provide a comprehensive idea about the spectrum of main problems, essentially presenting a number of basic principles to save as many lives as possible after natural and man-made mega disasters.
Discussion: Medical problems following disasters may be acute, acute-on-chronic, or chronic; they appear from the disaster period up till long thereafter.
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