AI Article Synopsis
- MRI studies often overlook unmedicated, non-White girls with ADHD, focusing mostly on male children.
- The study aimed to compare gray matter density in the cerebellum of unmedicated, non-White females with ADHD-C to healthy controls across different ages.
- Results indicated reduced gray matter density in the right cerebellar hemisphere, suggesting a consistent anatomical abnormality in unmedicated Hispanic girls with ADHD-C from childhood into adulthood.
Article Abstract
Background: MRI studies have shown a decreased cerebellum volume in individuals with ADHD. However, most of these studies were conducted with male children, many of whom were medicated with stimulants. As such, unmedicated, non-White girls are underrepresented in such MRI studies.
Objective: The aim of the present study was to compare the density of gray matter (GM) in the cerebellar hemisphere between unmedicated, non-White female children, adolescents, and adults diagnosed with ADHD combined type (ADHD-C) and healthy controls.
Method: MRIs were performed on 11 Hispanic unmedicated ADHD-C children (6-10 years old), 8 Hispanic adolescents (14-17 years old), 10 Hispanic adults (25-35 years old), and the respective healthy controls. Image processing and statistical analyses were performed by Voxel Based Morphometry using the DARTEL algorithm to improve spatial normalization.
Results: Reduced GM density located in the right cerebellar hemisphere was found in female children, adolescents, and adults with ADHD-C.
Conclusions: These findings suggest that there is an anatomical abnormality in the right cerebellar hemisphere in unmedicated Hispanic girls with ADHD-C that is present from childhood to adulthood.
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| http://dx.doi.org/10.1177/1087054710366421 | DOI Listing |
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