AI Article Synopsis
- - Two new series of formyl peptide receptor 1 (FPR1) antagonists have been identified, specifically methionine benzimidazole 6 and diamide 7
- - Both antagonists are effective at preventing the binding of a labeled peptide (fMLF) to hrFPR1, which indicates their potential in research applications
- - They selectively inhibit FPR1 function in human neutrophils, suggesting they could be valuable tools in laboratory experiments to validate FPR1 as a target
Article Abstract
The identification of two novel series of formyl peptide receptor 1 (FPR1) antagonists are reported, represented by methionine benzimidazole 6 and diamide 7. Both series specifically inhibited the binding of labelled fMLF to hrFPR1 and selectively antagonized FPR1 function in human neutrophils, making them useful in vitro validation tools for the target.
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| http://dx.doi.org/10.1016/j.bmcl.2011.03.049 | DOI Listing |
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