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Treatment of emphysematous polycystic renal infection in patients with autosomal dominant polycystic kidney disease: Feasibility and limitations of percutaneous cyst drainage.
Clin Nephrol Case Stud
December 2024
Nephrology Center and the Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.
Emphysematous polycystic renal infection (EPRI) has a poor prognosis with conservative management, and early surgical nephrectomy has been recommended. However, percutaneous cyst drainage may be a possible treatment option. We experienced 6 patients with autosomal dominant polycystic kidney disease (ADPKD) presenting with EPRI.
View Article and Find Full Text PDFAdvancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.
Regen Biomater
November 2024
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Nanohydroxyapatite (nHA) is distinguished by its exceptional biocompatibility, bioactivity and biodegradability, qualities attributed to its similarity to the mineral component of human bone. This review discusses the synthesis techniques of nHA, highlighting how these methods shape its physicochemical attributes and, in turn, its utility in biomedical applications. The versatility of nHA is further enhanced by doping with biologically significant ions like magnesium or zinc, which can improve its bioactivity and confer therapeutic properties.
View Article and Find Full Text PDFA specific and adaptable approach to track CD206 macrophages by molecular MRI and fluorescence imaging.
Theranostics
January 2025
Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, MA.
The mannose receptor (CD206, expressed by the gene ) is a surface marker overexpressed by anti-inflammatory and pro-tumoral macrophages. As such, CD206 macrophages play key roles in the immune response to different pathophysiological conditions and represent a promising diagnostic and therapeutic target. However, methods to specifically target these cells remain challenging.
View Article and Find Full Text PDFHemi-Gastrocnemius Hemi-Soleus Bi-pedicled Muscle Flap and Bone Transport in Reconstruction of Bone and Soft Tissue Defects in an Open Fracture Tibia Gustilo Type IIIc.
Cureus
December 2024
Hand and Microsurgery Unit, Trauma and Orthopedic Department, Rashid Hospital, Dubai Health Authority, Dubai, ARE.
Soft tissue injury in open fracture of the lower extremity represents a challenging trauma that requires complex strategies to reconstruct both bony and soft tissue defects. Various options are available to cover the soft tissue defect in the lower extremities, from simple skin grafting to local fasciocutaneous and muscle flaps. However, when the injury is extensive and involves a large surface area, options for treatment of local flap coverage become limited.
View Article and Find Full Text PDFLigand protonation leads to highly fluorescent boronium cations.
Chem Sci
December 2024
Department of Chemistry, The University of Western Ontario London Ontario N6A 5B7 Canada
Fluorophores that respond to external stimuli, such as changes in pH, have utility in bio-imaging and sensing applications. Almost all pH-responsive fluorophores rely on complex syntheses and the use of pH-responsive functional groups that are peripheral to the fluorophore framework. In this work, pH-responsive boron-containing heterocycles based on tridentate acyl pyridylhydrazone ligands were prepared.
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