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Surgical treatment of post-traumatic vertebral osteonecrosis including intravertebral expansive implants-clinical, functional and imaging outcomes and a center experience over 7 years.
J Spine Surg
September 2024
Spine Surgery Unit, Department of Orthopedics, Coimbra Hospital and University Centre, Coimbra, Portugal.
Background: The effective treatment of post-traumatic vertebral osteonecrosis continues to be an under discussion and controversial subject. Armed kyphoplasty with expansive intravertebral implants is an emerging procedure, which, in theory, allow for a more effective preservation of the restored vertebral height. The development of the indications for these recent devices has given rise to auspicious outcomes in vertebral non-union situations.
View Article and Find Full Text PDFCerebro-spinal flow pattern in the cervical subarachnoid space of healthy volunteers: Influence of the spinal cord morphology.
PLoS One
August 2024
Laboratoire de Biomécanique Appliquée, UMRT24, Aix Marseille Université, Marseille, France.
Introduction: Toward further cerebro-spinal flow quantification in clinical practice, this study aims at assessing the variations in the cerebro spinal fluid flow pattern associated with change in the morphology of the subarachnoid space of the cervical canal of healthy humans by developing a computational fluid dynamics model.
Methods: 3D T2-space MRI sequence images of the cervical spine were used to segment 11 cervical subarachnoid space. Model validation (time-step, mesh size, size and number of boundary layers, influences of parted inflow and inflow continuous velocity) was performed a 40-year-old patient-specific model.
Incidence and prognostic factors of residual back pain in patients treated for osteoporotic vertebral compression fractures: a systematic review and meta-analysis.
Eur Spine J
December 2024
Department of Orthopedic Surgery, the Key Laboratory of Digital Orthopaedics of Yunnan Province, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming City, 650034, Yunnan Province, China.
Article Synopsis
- - Osteoporotic vertebral compression fractures (OVCFs) can lead to ongoing back pain even after treatment, with varying rates of residual pain reported, highlighting the need for more research on risk factors.
- - A systematic review of 19 studies revealed that 16% of patients experience residual back pain (RBP) and 18% have cement leakage post-treatment, with several factors like gender, bone mineral density, and history of fractures linked to RBP.
- - The study emphasizes the importance of understanding RBP's risk factors to help doctors identify high-risk patients and improve treatment strategies, while future research should work on standardizing definitions and patient selection for better outcomes.
Consecutive Kummell's Disease Combined with Parkinson's Disease and Experienced Internal Fixation Failure: A Case Report and Literature Review.
Orthop Surg
July 2022
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.
Background: The continuous occurrence of Kummell's disease is extremely rare in clinical practice, and its treatment is difficult. The study aimed to present a rare case of consecutive Kummell's disease combined with Parkinson's disease (PD) and experienced internal fixation failure.
Case Presentation: A 69-year-old female patient had a history of PD for 10 years, and was treated by posterior decompression, fixation, and fusion because of Kummell's disease of T12 with neurological damage.
A rat model of valproate teratogenicity from chronic oral treatment during pregnancy.
Epilepsia
June 2020
Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia.
Objective: Sodium valproate (VPA), the most effective antiepileptic drug for patients with genetic generalized epilepsy (GGE), is a potent human teratogen that increases the risk of a range of congenital malformations, including spina bifida. The mechanisms underlying this teratogenicity are not known, but may involve genetic risk factors. This study aimed to develop an animal model of VPA-induced birth defects.
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