In 2008, the New Zealand Government passed an amendment to reschedule what were, at the time, the active ingredients of 'party pills' in New Zealand. Since then, submissions of tablets and powders to the Institute of Environmental Science and Research (ESR) Limited have included ingredients not previously seen among drug seizures in New Zealand. These new components, confirmed by the synthesis of standards, included some beta-ketone (βk) analogues of 3,4-methylenedioxyamphetamine (MDA). Though not yet seen in tablet or powder seizures, the synthesis and the analytical data for βk-DMBDB ((beta-ketone)-N,N-dimethyl-1-(1,3-benzodioxol-5-yl)-2-butanamine) are reported here for the first time.
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Talanta
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Centre for Chemistry and Biotechnology, Deakin University, Geelong, Victoria 3216, Australia.
We present an exploration of the chemiluminescence from reactions of benzylpiperazines and phenylpiperazines with tris(2,2'-bipyridine)ruthenium(III). The selectivity of the reagent towards these compounds was found to be highly dependent upon the pH of the solution, and the relative emission intensity was strongly influenced by electron donating or withdrawing substituents on the phenyl or benzyl ring. In spite of previous investigations showing poor responses for aromatic-substituted amines (compared to their aliphatic amine counterparts), intense emissions were observed with phenylpiperazines under acidic conditions, particularly those with halogen or trifluoromethyl substituents on the aromatic ring.
View Article and Find Full Text PDFPharmaceutical quality of "party pills" raises additional safety concerns in the use of illicit recreational drugs.
N Z Med J
June 2013
Discipline of Pharmacy, School of Medical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
Aim: To determine the content and release kinetics of 1-benzylpiperazine (BZP) and 1-(3-trifluoromethyl-phenyl)piperazine (TFMPP) from "party pill" formulations. From these data, the possible impact of pharmaceutical quality upon the safety of such illicit formulations may be inferred.
Methods: The amount of BZP and TFMPP in party pill formulations was determined using a validated HPLC method.
Estrogenic effects and their action mechanism of the major active components of party pill drugs.
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School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon dong, Jangan-gu, Suwon, Kyeonggi-do 440-746, South Korea.
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View Article and Find Full Text PDFSubjective effects in humans following administration of party pill drugs BZP and TFMPP alone and in combination.
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School of Pharmacy, University of Auckland, New Zealand.
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