The rapid speed of the recent rise in obesity rates suggest environmental causes. There is therefore a need to determine which components of the environment may be contributing to this increase. In this cross-sectional study, we examined the associations between adiposity and the characteristics of areas around homes, schools and routes to school among 1995 9-10 year old boys and girls in Norfolk, UK. The relationships between Fat Mass Index (FMI, calculated as fat mass (kg)/height (m)(2)) and objectively computed environmental indicators describing access to food outlets and physical activity facilities, the safety and connectivity of the road network, and the mix of land uses present were investigated. Multivariable hierarchical regression models were fitted with log-transformed FMI as the outcome, and stratification by gender and mode of travel to school. Among girls, better access to healthy food outlets (supermarkets and greengrocers) in the home environment was associated with lower FMI while better access to unhealthy outlets (takeaways and convenience stores) around homes and schools was associated with higher FMI. Also in girls, a higher proportion of accessible open land and a lower mix of land uses around the school were associated with higher FMI. Among boys the presence of major roads in the home neighbourhood was associated with higher FMI among non-active travellers, while major roads in the school neighbourhood were associated with lower FMI among active travellers. No significant associations were seen between FMI and any of the route characteristics. While the relative paucity of associations provides few indicators for the design of effective interventions, there was some evidence that environmental characteristics may be more important among active travellers than non-active travellers, and among girls than boys, suggesting that future interventions should be sensitive to such differences.
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http://dx.doi.org/10.1016/j.socscimed.2011.02.023 | DOI Listing |
J Am Soc Nephrol
January 2025
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Background: Cardiac surgery-associated acute kidney injury is a common serious complication after cardiac surgery. Currently, there are no specific pharmacological therapies. Our understanding of its pathophysiology remains preliminary.
View Article and Find Full Text PDFNeuro Oncol
January 2025
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Background: Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied, but is limited.
Methods: We performed genetic ancestry prediction in 1,452 pediatric patients with paired normal and tumor whole genome sequencing from the Open Pediatric Cancer (OpenPedCan) project to evaluate the influence of reported race and ethnicity and ancestry-based genetic superpopulations on tumor histology, molecular subtype, survival, and treatment.
J Med Internet Res
January 2025
Institute of Learning Sciences and Technologies, National Tsing Hua University, Hsinchu, Taiwan.
Background: Health misinformation undermines responses to health crises, with social media amplifying the issue. Although organizations work to correct misinformation, challenges persist due to reasons such as the difficulty of effectively sharing corrections and information being overwhelming. At the same time, social media offers valuable interactive data, enabling researchers to analyze user engagement with health misinformation corrections and refine content design strategies.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Background: This study was aimed to explore the global burden and trends of Clostridioides difficile infections (CDI) associated diseases.
Methods: Data for this study were obtained from the Global Burden of Disease Study 2021. The burden of CDI was assessed using the age-standardized rates of disability-adjusted life years (ASR-DALYs) and deaths (ASDRs).
JAMA Netw Open
January 2025
Division of Research, Kaiser Permanente Northern California, Pleasanton.
Importance: Food insecurity is a growing public health concern, but its association with perinatal complications remains unclear.
Objective: To examine whether food insecurity in pregnancy was associated with the risk of perinatal complications and determine whether these potential associations differed by receipt of food assistance.
Design, Setting, And Participants: This cohort study used data from a pregnancy survey conducted between June 22, 2020, and September 9, 2022, at Kaiser Permanente Northern California, an integrated health care system serving a diverse population of 4.
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