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| http://dx.doi.org/10.1111/j.1365-2125.2011.03976.x | DOI Listing |
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Opioid Allergy Cross-Reactivity: A Retrospective Study Across Three Opioid Classes.
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Lexington VA Health Care System, Lexington, Kentucky, USA.
IgE-mediated opioid hypersensitivities, or true allergies, are rare and most adverse reactions to opioids can be attributed to side effects or to pseudo-allergies. Given that immune-mediated allergies to opioids are uncommon, literature regarding cross-reactivity among opioid classes are limited. This retrospective study aimed to determine the rates of cross-reactivity and tolerance among patients with previously documented opioid allergy or adverse drug reaction (ADR) across three opioid drug classes (natural, semisynthetic, and synthetic opioids).
View Article and Find Full Text PDFUrsolic acid attenuates pseudo-allergic reactions via reducing MRGPRX2-mediated mast cell degranulation.
Immunol Lett
December 2024
Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China. Electronic address:
Mas-related G protein-coupled receptor X2 (MRGPRX2) is a newly identified receptor on mast cells that contribute to IgE-independent pseudo-allergy. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported for its anti-allergy effects. However, the protective mechanism against pseudo-allergic reactions remains unclear.
View Article and Find Full Text PDFInhibition of pseudo-allergic reactions by vitamin K3 directly targeting GAB1 in mast cells.
Int Immunopharmacol
August 2024
School of Pharmacy, Xi'an Jiaotong University, Xi'an, China. Electronic address:
Background: Vitamin K3 (VK3), a fat-soluble synthetic analog of the vitamin K family, has coagulant, anti-inflammatory, antibacterial, and anticancer properties. Pseudo allergy is a IgE-independent immune response associated with mast cells. This study investigated the role of VK3 in IgE-independent mast cell activation.
View Article and Find Full Text PDFAGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.
Clin Gastroenterol Hepatol
August 2024
Digestive Disease Research Center, Medical University of South Carolina, Charleston, South Carolina.
Description: In this Clinical Practice Update (CPU), we will Best Practice Advice (BPA) guidance on the appropriate management of iron deficiency anemia.
Methods: This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. These Best Practice Advice (BPA) statements were drawn from a review of the published literature and from expert opinion.
Complement-mediated dialysis reaction during regular hemodialysis treatment: a case report.
J Med Case Rep
February 2024
SeroScience Ltd., Budapest, Hungary.
Background: Hemodialysis reactions (HDRs) are similar to complement activation-related pseudo allergy (CARPA), a hypersensitivity reaction that occurs when administering certain (nano)drugs intravenously. The pathomechanism of CARPA was described based on animal experiments. Typical CARPA-like dialysis reactions, which occur at the start of hemodialysis, have been reported using polysulfone dialyzers.
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