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A Roadmap of Responses to Asymmetry Stress in Lipid Membranes.
J Phys Chem B
January 2025
Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany.
The selective insertion of membrane-impermeant amphiphiles such as detergents, (lipo)peptides, drugs, etc. into the leaflet of a membrane causes an imbalance between the intrinsic areas of the and leaflet, referred to as asymmetry stress or differential stress. The literature provides individual mechanisms of how membranes respond to such stress, which are relevant to membrane remodeling processes and leakage phenomena.
View Article and Find Full Text PDFThe Flip Side of the Coin: Giftedness in Pediatric Acute-Onset Neuropsychiatric Syndrome.
Children (Basel)
December 2024
Department of Rehabilitation Science, University at Buffalo, Buffalo, NY 14214, USA.
Individuals with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), an immune-modulated disorder, experience exacerbation-related neuropsychiatric symptoms, functional impairments, and high rates of developmental diagnosis. The literature describes links between giftedness and mental illness, and giftedness and autoimmune disorders. We sought to explore rates of giftedness among children with PANS as perceived by their caregivers, and to examine whether giftedness was related to PANS symptom severity, persistence, or duration.
View Article and Find Full Text PDFGroup 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway.
Am J Transplant
December 2024
The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA. Electronic address:
As important immune regulatory cells, whether innate lymphoid cells (ILCs) are involved in liver transplantation (LT) remains unclear. In a murine orthotopic LT model, we dissected roles of ILCs in liver ischemia-reperfusion injury (IRI). Wild-type (WT) grafts suffered significantly higher IRI in Rag2-γc double knockout (DKO) than Rag2 knockout (KO) recipients, in association with downregulation of group 1 ILCs genes, including interferon gamma.
View Article and Find Full Text PDFThe C-terminal activating domain promotes pannexin 1 channel opening.
Proc Natl Acad Sci U S A
December 2024
Department of Molecular Medicine, Cornell University, Ithaca, NY 14853.
Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore. However, this simple pore-plugging mechanism alone cannot account for the observation that a Panx1 construct ending before the caspase cleavage site remains closed.
View Article and Find Full Text PDFThe utility of small nutation angle H pulses for NMR studies of methyl-containing side-chain dynamics in proteins.
Prog Nucl Magn Reson Spectrosc
December 2024
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, United States. Electronic address:
We describe the utility of small nutation angle (acute; <90°) H radiofrequency pulses for efficient manipulation of magnetization in selectively [CH]-labeled methyl groups of otherwise deuterated proteins. Focusing primarily on NMR applications that target either fast (pico-to-nanosecond) motions of the methyl group three-fold rotation axis, or slow (micro-to-millisecond) processes associated with chemical exchange, we show that significant simplification of the CH spin-system and, as a consequence, of NMR pulse schemes, may be achieved in certain cases by the proper choice of the flip-angle of the H acute-angle pulse. In other instances, appropriate adjustment of acute-angle H pulses permits optimization of the sensitivity of NMR experiments.
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