AI Article Synopsis
- This study investigates how sun exposure during childhood relates to the risk of developing melanoma in young adults (ages 18-39).
- Researchers analyzed data from over a thousand participants, comparing those diagnosed with melanoma to controls, using interviews to gather information about sun exposure.
- Findings indicate that while overall childhood sun exposure doesn't show a strong link to melanoma, it does seem to increase the risk for those diagnosed between 18-29 years old, especially for individuals who tan rather than burn and have fewer moles.
Article Abstract
Objective: To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years.
Methods: Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders.
Results: Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P (trend) 0.02; P (interaction) by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P (trend) 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi.
Conclusion: The association of early-life sun exposure with early-onset melanoma is influenced by host factors.
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| http://dx.doi.org/10.1007/s10552-011-9762-3 | DOI Listing |
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