AI Article Synopsis
- The research focused on creating new chemical compounds: 2-carboxymethylsulfanylmethyl-1H-benzimidazole and 1,3-dihydro-4H-benzo[4',5']imidazo[2,1-c][1,4]thiazine-4-one-8-carboxylic acid.
- The antiviral effectiveness of 14 synthesized compounds was tested against herpes simplex virus 1.
- Compounds 5 and 14 demonstrated strong antiviral activity, inhibiting virus spread by 94.7% and 91.3% at a dosage of 50 µg, outperforming Acyclovir at lower dosages.
Article Abstract
The synthesis of new 2-carboxymethylsulfanylmethyl-1H-benzimidazole and 1,3-dihydro-4H-benzo[4',5']imidazo[2,1-c][1,4]thiazine-4-one-8-carboxylic acid derivatives was investigated. The antiviral activity of compounds 1-14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 µg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 µg and 50 µg.
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| http://dx.doi.org/10.1002/ardp.201000252 | DOI Listing |
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