In eukaryotes transcription is complicated by the DNA being packed in nucleosomes and by supercoils induced by opening of the DNA double helix during elongation. Here we discuss our recent genome-wide work regarding topoisomerases and their role in chromatin remodeling during the transcription cycle and we report a novel function for topoisomerases in transcription termination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062396 | PMC |
| http://dx.doi.org/10.4161/trns.2.2.14411 | DOI Listing |
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