Visceral states are known to reduce the ability to exert self-control. In the current research, we investigated how self-control is affected by a visceral factor associated with inhibition rather than with approach: bladder control. We designed four studies to test the hypothesis that inhibitory signals are not domain-specific but can spill over to unrelated domains, resulting in increased impulse control in the behavioral domain. In Study 1, participants' urination urgency correlated with performance on color-naming but not word-meaning trials of a Stroop task. In Studies 2 and 3, we found that higher levels of bladder pressure resulted in an increased ability to resist impulsive choices in monetary decision making. We found that inhibitory spillover effects are moderated by sensitivity of the Behavioral Inhibition System (Study 3) and can be induced by exogenous cues (Study 4). Implications for inhibition and impulse-control theories are discussed.
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http://dx.doi.org/10.1177/0956797611404901 | DOI Listing |
J Environ Manage
December 2024
School of Economics and Management, Chang'an University, Xi'an, Shaanxi, 710064, China. Electronic address:
Faced with increasingly severe climate and energy crises, promoting renewable energy development has become an inevitable choice for realizing carbon reduction strategy and energy structure transformation. This paper selects the panel data of 30 provinces in China from 2001 to 2021 and constructs a dynamic spatial Durbin model to study the effect of renewable energy development on carbon emission intensity. The study shows a significant positive spatial correlation between renewable energy development and carbon emission intensity in Chinese provinces.
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
Laboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas de Abel Salazar Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal; Centro de Investigação Farmacológica e Inovação Medicamentosa (MedInUP/RISE-Health), Instituto de Ciências Biomédicas de Abel Salazar Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal. Electronic address:
Nicotinic α7 receptors (α7 nAChRs) present in perisynaptic Schwann cells (PSCs) control acetylcholine (ACh) spillover from the neuromuscular synapse by transiently increasing intracellular Ca, which fosters adenosine release via type 1 equilibrative nucleoside transporters (ENT1) and retrograde activation of presynaptic A inhibitory receptors. The putative Ca-dependent pathways downstream α7 nAChRs involved in the sensing inhibitory drive operated by PSCs is unknown. Herein, we used phrenic nerve-hemidiaphragm preparations from Wistar rats.
View Article and Find Full Text PDFMed Microbiol Immunol
November 2024
Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
The concern of COVID-19 persists due to the continuous emergence of variants and the potential spillover of animal coronaviruses. The broad-spectrum neutralizing antibodies play a pivotal role in the prevention and treatment of coronavirus (CoV) infections. Here, we constructed 18 bi-specific antibodies (bsAbs) using 9 antibodies isolated from COVID-19 convalescents and vaccinated individuals, designed as dual variable domain immunoglobulin (DVD-Ig).
View Article and Find Full Text PDFImmunity
December 2024
Department of Biochemistry, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, Seattle, WA 98195, USA. Electronic address:
Porcine delta-coronavirus (PDCoV) spillovers were recently detected in febrile children, underscoring the recurrent zoonoses of divergent CoVs. To date, no vaccines or specific therapeutics are approved for use in humans against PDCoV. To prepare for possible future PDCoV epidemics, we isolated PDCoV spike (S)-directed monoclonal antibodies (mAbs) from humanized mice and found that two, designated PD33 and PD41, broadly neutralized a panel of PDCoV variants.
View Article and Find Full Text PDFNPJ Vaccines
October 2024
College of Basic Medical Sciences, Hengyang Medical School, University of South China & MOE Key Lab of Rare Pediatric Diseases, Hengyang, 421001, China.
The outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2 highlight the need for countermeasures to prevent future coronavirus pandemics. Given the unpredictable nature of spillover events, preparing antibodies with broad coronavirus-neutralizing activity is an ideal proactive strategy. Here, we investigated whether SARS-CoV-2 infection and vaccination could provide cross-neutralizing antibodies (nAbs) against zoonotic sarbecoviruses.
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