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as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants.
Front Neurosci
January 2023
Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.
Mutations in the human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) can instigate myoclonic-atonic and other generalized epilepsies in the afflicted individuals. We systematically examined fifteen hGAT-1 disease variants, all of which dramatically reduced or completely abolished GABA uptake activity. Many of these loss-of-function variants were absent from their regular site of action at the cell surface, due to protein misfolding and/or impaired trafficking machinery (as verified by confocal microscopy and de-glycosylation experiments).
View Article and Find Full Text PDFThe role of adiponectin in human vascular physiology.
Int J Cardiol
March 2012
Department of Experimental Physiology, Athens University School of Medicine, Greece.
Adiponectin (ApN) is an adipose tissue-derived hormone which is involved in a wide variety of physiological processes including energy metabolism, inflammation, and vascular physiology via actions on a broad spectrum of target organs including liver, skeletal muscle, and vascular endothelium. Besides possessing insulin sensitizing and anti-inflammatory properties ApN also exerts a pivotal role in vascular protection through activation of multiple intracellular signaling cascades. Enhancement of nitric oxide generation and attenuation of reactive oxygen species production in endothelial cells along with reduced vascular smooth muscle cell proliferation and migration constitute some of ApN's vasoprotective actions.
View Article and Find Full Text PDFA hundred years after psychoanalysis was introduced, neuroscience has taken a giant step forward. It seems nowadays that effects of psychotherapy could be monitored and measured by state-of-the art brain imaging techniques. Today, the psychotherapy is considered as a strategic and purposeful environmental influence intended to enhance learning.
View Article and Find Full Text PDF[Rational pharmaco-therapeutic algorithms for the management of Alzheimer's disease].
Zh Nevrol Psikhiatr Im S S Korsakova
May 2011
[Diagnostic and pharmaco-therapeutic options in acute severe blood loss].
Ned Tijdschr Geneeskd
September 2004
Afd. Algemeen Interne Geneeskunde, Sectie Vasculaire Geneeskunde, Universitair Medisch Centrum St Radboud, Nijmegen.
In patients with excessive blood loss, coagulation is compromised by hypothermia, metabolic acidosis due to impaired tissue perfusion, loss of coagulation factors and platelets while their consumption is increased, and by massive infusion with plasma expanders. Currently available laboratory tests are insufficiently reliable and too time-consuming to enable the evaluation of the effect of pharmaco-therapeutic interventions during severe blood loss. Several haemostatic drugs appear to be effective in the treatment of blood loss after elective surgery, but have been insufficiently investigated in patients with severe bleeding.
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