The incidence of iatrogenic peripheral nerve injury during hip arthroplasty procedures has been reported to be between 0.6 and 1.3 percent. The relative risk of nerve palsy is higher in certain groups of patients such as women, patients with developmental dysplasia of the hip, and those who have undergone revision arthroplasty. In this study, the dynamic relationship between the acetabulum and the sciatic nerve, which is important for preventing sciatic nerve palsy during the hip surgery, was investigated. The sciatic nerve was exposed in 69 cadaveric hips. The relationship between the bony acetabulum and the sciatic nerve was examined in three different positions; as the ipsilateral hip was flexed; extended; or in neutral position. We found that the middle part of the posterior acetabular rim was closer to the sciatic nerve than its superior or inferior parts. The sciatic nerve was perilous when the ipsilateral hip was flexed and the middle part of the posterior acetabular rim was more risky than the superior or inferior parts, in terms of iatrogenic sciatic nerve injury.
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http://dx.doi.org/10.5301/HIP.2011.6491 | DOI Listing |
J Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Anatomy, School of Medicine, Marmara University, Basibuyuk Yolu, Maltepe, Istanbul, Turkey (Dr. Ismailoglu, Dr. Sehirli, and Dr. Ayingen); the Department of Anatomy, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, Turkey (Dr. Bayramoglu and Dr. Savasan); and the Department of Orthopedic Surgery, Faculty of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, Turkey (Dr. Kocaoglu).
Purpose: The surgical approach for midfoot injuries classically requires dual dorsal incision and identification of the neurovascular structures that are susceptible to injury during the surgery. The aim of this study was to map the topographic anatomy of the dorsum of the foot along with tarsal joints for the dorsal approach of midfoot surgery that would facilitate the surgery and minimize the risk of neurovascular injuries for surgeons who specially focus on foot and ankle injuries.
Methods: The dorsum of the foot was evaluated in 12 feet injected with latex containing a red colorant to visualize the arterial vessels.
Chin Med
January 2025
Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China.
Background: Paclitaxel-induced peripheral neuropathy (PIPN) is prevalent among patients receiving paclitaxel chemotherapy, which results in sensory abnormality as well as neuropathic pain. Conventional medications lack effectiveness on PIPN. Clinical trials identified beneficial effects of acupuncture on PIPN among patients receiving chemotherapy.
View Article and Find Full Text PDFPathogenic variants of GDAP1 cause Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by axonal degeneration. GDAP1, an atypical glutathione S-transferase, localizes to the outer mitochondrial membrane (OMM), regulating this organelle's dynamics, transport, and membrane contact sites (MCSs). It has been proposed that GDAP1 functions as a cellular redox sensor.
View Article and Find Full Text PDFEur J Pharm Biopharm
January 2025
National Advanced Medical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai 201203 PR China. Electronic address:
Current analgesics on the market exhibit a short duration of action and induce the production of inflammatory factors in tissues damaged by surgical procedures. Inflammatory factor production can create acidic environments, limiting drug delivery. In this study, we developed a novel injectable formulation comprising bupivacaine multivesicular liposomes of high osmotic pressure (H-MVL) and meloxicam nanocrystals (MLX) in a thermosensitive gel (H-MVL/MLX@GEL) adapted to the microenvironment for long-term postoperative analgesia.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
January 2025
Harran University Faculty of Veterinary Medicine Department of Anatomy, Sanliurfa, Turkey.
A pathological condition in the peripheral nerve tissue, which provides the connection between the organism and the external environment, negatively affects the standard of living. The nerve tissue histotechnology is of serious importance both for scientific studies and for clinical diagnosis. The fixation, which is one of the leading procedures for histological examination of tissues, aims to preserve tissue morphology.
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