AI Article Synopsis
- The study investigates the antidepressant effects of Hypericum montbretti flower extract, focusing on its phytochemical components, particularly rutin and quercitrin.
- Antidepressant activity was tested using tail suspension and forced swimming tests, with the extract showing dose-dependent effects at 100 and 250 mg/kg compared to the reference drug, Reboxetine.
- This research is notable as it is the first to report the antidepressant activity of H. montbretti extract, reinforcing previous findings regarding rutin's effectiveness.
Article Abstract
This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic extract were analysed by HPLC method. The main flavonoid component was detected as rutin, and another highly concentrated phenolic compound was quercitrin. Antidepressant activity of the extract was examined by tail suspension and modified forced swimming tests, whereas the motor coordination of the animals was tested by the Rota-Rod apparatus. Reboxetine at a dose of 20 mg kg⁻¹ was used as a reference drug. Dose-dependent antidepressant activity was observed in both tests following the administration of extract at 100 and 250 mg kg⁻¹ doses. To the best of our knowledge, this is the first study reporting the antidepressant activity of H. montbretti extract. Additionally, the results of this work support previous papers reporting the antidepressant activity of rutin.
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| http://dx.doi.org/10.1080/14786419.2011.557800 | DOI Listing |
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