We report a rare case of optic nerve atrophy with severe disc cupping resulting from methanol poisoning. A 30-year-old man presented to the hospital complaining of decreased visual acuity in both eyes a day after drinking alcohol containing methanol. His initial visual acuity allowed for only visualizing hand motion and not corrected in either eye. Initial intraocular pressure was within normal limits in both eyes. Initial fundus examination showed optic disc swelling in both eyes. Four years later, he visited our hospital for an eye evaluation. Visual acuity in both eyes still only allowed for visualizing hand motion. No nystagmus was observed in either eye during the optokinetic nystagmus test, and no waves were found in a visual evoked potential test. No specific change was noted on brain magnetic resonance imaging. On fundus examination, there was disc pallor in both eyes and disc cupping with a high cup/disc (C/D) ratio above 0.9 in the left eye. C/D ratio of the right eye was 0.5. Methanol poisoning may induce glaucomatous disc cupping in the late stage as well as optic atrophy. One possible mechanism of disc cupping is ganglion cell loss due to acute demyelination of the retrobulbar optic nerve. This report is the first photographic evidence of methanol induced optic disc cupping in Korea.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060395 | PMC |
| http://dx.doi.org/10.3341/kjo.2011.25.2.146 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Peripapillary Vascular Density Differentiates Glaucomatous Cupping From Physiological Cupping Using Optical Coherence Tomography Angiography.
J Glaucoma
December 2024
Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Prcis: In glaucoma, peripapillary vascular density was reduced compared to normal eyes, with or without physiological cupping.
Purpose: To assess the ability of radial peripapillary capillaries vessel density (RPC VD) to distinguish between physiological and glaucomatous cupping using optical coherence tomography angiography (OCTA).
Patients And Methods: An observational study was conducted at Ain Shams University, involving 98 eyes from 98 patients, divided into three groups.
A deep learning framework for the early detection of multi-retinal diseases.
PLoS One
July 2024
Information Technology Department, College of Computer and Information Sciences, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Retinal images play a pivotal contribution to the diagnosis of various ocular conditions by ophthalmologists. Extensive research was conducted to enable early detection and timely treatment using deep learning algorithms for retinal fundus images. Quick diagnosis and treatment planning can be facilitated by deep learning models' ability to process images rapidly and deliver outcomes instantly.
View Article and Find Full Text PDFAutomated Optic Nerve Head Hemoglobin Measurements versus General Ophthalmologists Evaluation to Differentiate Glaucomatous from Large Physiological Cupping: A Diagnostic Performance Comparative Study.
Clin Ophthalmol
July 2024
Department of Ophthalmology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
Purpose: The aim of this study is to compare the diagnostic performance in differentiating patients with glaucoma from those with presumed large physiological optic disc cupping (LPC), using optic nerve head hemoglobin levels (ONH Hb), as a screening method, versus the evaluation of general ophthalmologists.
Patients And Methods: Twenty general ophthalmologists evaluated PowerPoint images of 40 patients with glaucoma and 40 presenting LPC. Presentation of patient's exams were distributed as follows: Group 1 (GI): color retinography (CR), Group 2 (GII): CR + visual field (VF), Group 3 (GIII): CR + optical coherence tomography (OCT), Group 4 (GIV): CR + VF + OCT.
Non-syndromic OTX2-associated pattern dystrophy: a 10-year multimodal imaging study.
Doc Ophthalmol
October 2024
Ocular Tissue Engineering Laboratory, Lions Eye Institute, Nedlands, WA, Australia.
Purpose: To report novel multimodal imaging features and long-term follow-up of Orthodenticle Homeobox 2 (OTX2)-associated pattern Gdystrophy.
Methods: A 14-year-old boy referred with glaucoma suspect and macular pigmentation underwent fundus autofluorescence imaging, optical coherence tomography, fluorescein and indocyanine green angiography, visual field test, microperimetry and electrophysiology over a ten-year period. Next-generation sequencing panel identified a de novo heterozygous likely pathogenic OTX2 variant, c.
Optic Disc Cupping in Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, and Multiple Sclerosis and Its Relationship With Optical Coherence Tomography Parameters: A Multicenter Study.
J Neuroophthalmol
July 2024
Department of Ophthalmology (TE, BKC), Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology (TE, RG), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Neuro-Ophthalmology Unit, Felsenstein Medical Research Center and Department of Ophthalmology (HS-K), Rabin Medical Center, Petah Tikva, Israel, and Tel Aviv University, Tel Aviv, Israel; Department of Neurology (LR, BKC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Division of Neuro-Ophthalmology (ADH), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neurology (ES, YS, GA), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neurology (DAT, EPF, NT, JJC), Mayo Clinic, Rochester, Minnesota; and Departments of Ophthalmology and Neurology (JJC), Mayo Clinic, Rochester, Minnesota.
Background: Although cupping of the optic nerve is classically a sign of glaucomatous optic neuropathy, it has been shown that cupping can sometimes occur after an episode of optic neuritis (ON). The purpose of this study was to compare cupping in patients after ON from multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the relationship between cupping and retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thinning.
Methods: This was a retrospective cohort involving patients (≥18 years) with ON from 3 institutions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!