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Proteomic studies on protein modification by cyclopentenone prostaglandins: expanding our view on electrophile actions. | LitMetric

Proteomic studies on protein modification by cyclopentenone prostaglandins: expanding our view on electrophile actions.

J Proteomics

Chemical and Physical Biology Department, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.

Published: October 2011

AI Article Synopsis

  • - Cyclopentenone prostaglandins (cyPG) are lipid mediators that influence inflammation and tumor development by modifying cellular proteins through their electrophilic properties.
  • - Advances in proteomic techniques have identified many protein targets of cyPG, shedding light on their roles in inflammation resolution, cell proliferation, and redox regulation.
  • - Ongoing research faces challenges in detecting and measuring these protein modifications, but recent findings are leading to new understandings of electrophilic signaling and potential therapeutic applications.

Article Abstract

Cyclopentenone prostaglandins (cyPG) are lipid mediators that participate in the mechanisms regulating inflammation and tumorigenesis. cyPG are electrophilic compounds that act mainly through the covalent modification of cellular proteins. The stability of many cyPG-protein adducts makes them suitable for proteomic analysis. Indeed, methodological advances in recent years have allowed identifying many cyPG targets, including components of pro-inflammatory transcription factors, cytoskeletal proteins, signaling kinases and proteins involved in redox control. Insight into the diversity of cyPG targets is providing a better understanding of their mechanism of action, uncovering novel links between resolution of inflammation, proliferation and redox regulation. Moreover, identification of the target residues has unveiled the selectivity of protein modification by these electrophiles, providing valuable information for potential pharmacological applications. Among the challenges ahead, the detection of proteins modified by endogenous cyPG and the quantitative aspects of the modification require further efforts. Importantly, only a few years after the appearance of the first proteomic studies, research on cyPG targets is yielding new paradigms for redox and electrophilic signaling.

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Source
http://dx.doi.org/10.1016/j.jprot.2011.03.028DOI Listing

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