The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130849 | PMC |
| http://dx.doi.org/10.1016/j.micinf.2011.03.006 | DOI Listing |
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